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Anonymity is increasingly important for networked applications amidst concerns over censorship and privacy. This paper outlines the design of HerbivoreFS, a scalable and efficient file sharing system that provides strong anonymity. HerbivoreFS provides computational guarantees that even adversaries able to monitor all network traffic cannot deduce the(More)
Anonymity is increasingly important for networked applications amidst concerns over censorship and privacy. In this paper, we describe Herbivore, a peer-to-peer, scalable, tamper-resilient communication system that provides provable anonymity and privacy. Building on dining cryptographer networks, Herbivore scales by partitioning the network into(More)
BACKGROUND The prognostic significance of germline mutations in BRCA1 and BRCA2 in women with breast cancer remains unclear. A combined analysis was performed to address this uncertainty. METHODS Two retrospective cohorts of Ashkenazi Jewish women undergoing breast-conserving treatment for invasive cancer between 1980 and 1995 (n = 584) were established.(More)
BACKGROUND Germline mutations in CDH1 are associated with hereditary diffuse gastric cancer; lobular breast cancer also occurs excessively in families with such condition. METHOD To determine if CDH1 is a susceptibility gene for lobular breast cancer in women without a family history of diffuse gastric cancer, germline DNA was analysed for the presence of(More)
BACKGROUND Data for multiple common susceptibility alleles for breast cancer may be combined to identify women at different levels of breast cancer risk. Such stratification could guide preventive and screening strategies. However, empirical evidence for genetic risk stratification is lacking. METHODS We investigated the value of using 77 breast(More)
Anonymity is critical for many networked applications. Yet current Internet protocols provide no support for masking the identity of communication endpoints. This paper outlines a design for a peer-to-peer, scalable, tamper-resilient communication protocol that provides strong anonymity and privacy. Called CliqueNet, our protocol provides an(More)
Common genetic variants contribute to the observed variation in breast cancer risk for BRCA2 mutation carriers; those known to date have all been found through population-based genome-wide association studies (GWAS). To comprehensively identify breast cancer risk modifying loci for BRCA2 mutation carriers, we conducted a deep replication of an ongoing GWAS(More)
The genetics of lymphoma susceptibility reflect the marked heterogeneity of diseases that comprise this broad phenotype. However, multiple subtypes of lymphoma are observed in some families, suggesting shared pathways of genetic predisposition to these pathologically distinct entities. Using a two-stage GWAS, we tested 530,583 SNPs in 944 cases of lymphoma,(More)
BACKGROUND The high mortality rate associated with epithelial ovarian carcinoma (EOC) reflects diagnosis commonly at an advanced stage, but improved early detection is hindered by uncertainty as to the histologic origin and early natural history of this malignancy. METHODOLOGY/PRINCIPAL FINDINGS Here we report combined molecular genetic and morphologic(More)
Hereditary ovarian cancers associated with germline mutations in ei ther BRCAl or BRCA2 were studied to determine whether somatic mu tation of the /'.I.I gene is required for BRCA-linked ovarian tumorigenesis and further, whether the spectrum of additional somatic molecular genetic alterations present in these tumors differs from that known to exist in(More)