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Evidence-based medicine (EBM) has thus far failed to adequately account for the appropriate incorporation of other potential warrants for medical decision making into clinical practice. In particular, EBM has struggled with the value and integration of other kinds of medical knowledge, such as those derived from clinical experience or based on(More)
Cystic fibrosis (CF) is one of the most common autosomal recessive disorders in North America, leading to significant morbidity and early mortality. The defect in the cystic fibrosis transmembrane conductance regulator protein (CFTR) function can be corrected in vitro by gene replacement with a wild-type gene. A Phase I, single administration, dose(More)
*This Editorial may also be published by other medical or biomedical journals. T he proportion of older people in the general population is steadily increasing worldwide, with the most rapid growth in low-and middle-income countries [1]. This demographic change is to be celebrated , because it is the consequence of socioeconomic development and better life(More)
  • Carman Kl, Maurer M Mallery, +98 authors Dartmouth Iv
  • 2014
The Agency for Healthcare Research and Quality's (AHRQ) Effective Health Care Program conducts and supports research focused on the outcomes, effectiveness, comparative clinical effectiveness, and appropriateness of pharmaceuticals, devices, and health care services. More information on the Effective Health Care Program and electronic copies of this report(More)
Many critically ill persons are unable to participate in medical decision making, due, at least in part, to medications administered to provide sedation and analgesia. Such patients may retain the ability to participate to some degree in medical decisions if these medications can be reduced or eliminated. Decisions regarding the withdrawal of support, in(More)
  • M R Tonelli
  • 1998
Evidence-based medicine (EBM) has already had a profound effect on both medical education and clinical practice. The benefits of EBM, which defines the value of medical interventions in terms of empirical evidence from clinical trials, are enormous and well described. Not clearly acknowledged, however, are the limits of EBM. An intrinsic gap exists between(More)
Despite significant progress in therapy for cystic fibrosis (CF), most patients with the disease still die before the age of 30 years. Published discussions and descriptions of end-of-life care of patients with CF have been few, but interest in these issues is increasing. Descriptions of end-of-life care for persons with CF have begun to appear, and(More)
PURPOSE Family-clinician communication in the intensive care unit (ICU) about withholding and withdrawing life support occurs frequently, yet few data exist to guide clinicians in its conduct. The purpose of this study was to develop an understanding of the way this communication is currently conducted. METHODS We identified family conferences in the ICUs(More)