Mark R. McLean

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This report describes procedures we have developed for obtaining correlated quantitative structural information at two very different levels of resolution. Accurate reconstructions of entire organs and samples of tissue within organs were produced in correct scalar and topographical relationship using computer-assisted techniques. A specially designed(More)
OBJECTIVE To assess effectiveness and side effects of thiazolidinediones (TZDs) as adjunctive therapy in suboptimally controlled patients with type 2 diabetes. DESIGN AND SETTING Review of a prospectively recorded database at the Royal Melbourne Hospital diabetes clinic. PARTICIPANTS 203 patients with type 2 diabetes who received pioglitazone or(More)
Knowledge of the muscle pattern in the heart is important to understanding cardiac contraction and propagation of the electrical stimulus. Most work on this pattern has been carried out by blunt gross dissection, whereby fiber bundles are easily visible on the peeled heart wall. However, it has never been shown, to our knowledge, that the orientation of(More)
Three-dimensional (3-D) reconstructions from serial tissue sections produce a table of x, y, z coordinates (i.e., a numerical description of the object) that will support 3-D computer graphics displays and morphometric analyses. While measures such as volume or surface area can be generated interactively, almost instantaneously, they are usually of unknown(More)
AIMS Insulin secretion increases in normal pregnancy to meet increasing demands. Inability to increase beta-cell function results in gestational diabetes mellitus (GDM). We have previously shown that the expression of the transcription factor ARNT (Aryl-hydrocarbon Receptor Nuclear Translocator) is reduced in the islets of humans with type 2 diabetes. Mice(More)
OBJECTIVE We assessed the efficacy of routine glycated hemoglobin (HbA1c) testing to detect undiagnosed diabetes and prediabetes in an urban Australian public hospital emergency department (ED) located in an area of high diabetes prevalence. METHODS Over 6 weeks, all patients undergoing blood sampling in the ED had their random blood glucose measured. If(More)