Mark R. Holland

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Previous work from our laboratory showed that the widely reported decrease in phase velocity with frequency (negative dispersion) for ultrasonic waves propagating through trabecular bone can arise from the interference of two compressional waves, each of which exhibits a positive dispersion. Previous simulations suggest that Bayesian probability theory can(More)
Ultrasonic tissue characterization has shown promise for clinical diagnosis of diseased bone (e.g., osteoporosis) by establishing correlations between bone ultrasonic characteristics and the state of disease. Porous (trabecular) bone supports propagation of two compressional modes, a fast wave and a slow wave, each of which is characterized by an(More)
Quantitative ultrasonic characterization of cancellous bone can be complicated by artifacts introduced by analyzing acquired data consisting of two propagating waves (a fast wave and a slow wave) as if only one wave were present. Recovering the ultrasonic properties of overlapping fast and slow waves could therefore lead to enhancement of bone quality(More)
The left and right ventricular function of the heart are influenced by the complex structure of the ventricular septum. The cyclic variation of ultrasonic backscatter over the cardiac cycle is known to be sensitive to both structural and functional characteristics of the myocardium. The objective of this study was to investigate differences in the measured(More)
OBJECTIVE The purpose of this study was to determine whether resting myocardial deformation and rotation may be altered in diabetic patients with significant epicardial coronary artery disease (CAD) with normal left ventricular ejection fraction. DESIGN A prospective observational study. SETTING Diagnosis of epicardial CAD in patients with diabetes. (More)
Refereed Manuscripts 1. " Conventional, Bayesian, and Modified Prony's methods for characterizing fast and slow waves in equine cancellous bone, " Amber 4. " Effective-medium theory of elastic waves in random networks of rods " , 5. " Cancellous bone fast and slow waves obtained with Bayesian probability theory correlate with porosity from computer(More)
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