Mark R. Burge

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Weight-loss interventions generally improve lipid profiles and reduce cardiovascular disease risk, but effects are variable and may depend on genetic factors. We performed a genetic association analysis of data from 2,993 participants in the Diabetes Prevention Program to test the hypotheses that a genetic risk score (GRS) based on deleterious alleles at 32(More)
Diabetes afflicts an estimated 171 million people worldwide. Diabetic patients are at risk of a wide range of complications including peripheral neuropathy (or diabetic foot). The condition if left untreated will lead to ulcers and eventually lower extremity amputation. Current existing diagnostic techniques for peripheral neuropathy are mostly qualitative(More)
Adolescents Committed to Improvement of Nutrition and Physical Activity (ACTION) was undertaken to determine feasibility of a school-based health center (SBHC) weight management program. Two urban New Mexico SBHCs were randomized to deliver ACTION or standard care. ACTION consisted of eight visits using motivational interviewing to improve eating and(More)
OBJECTIVE This study was designed to compare the efficacy of acute premeal administration of glipizide versus nateglinide in controlling postprandial hyperglycemia in subjects with non-insulin-requiring type 2 diabetes. RESEARCH DESIGN AND METHODS A total of 20 subjects (10 female, 10 male) with non-insulin-requiring type 2 diabetes were admitted(More)
OBJECTIVE To explore the hypothesis that CD36, a scavenger receptor and fatty acid translocase, is upregulated in peripheral blood mononuclear cells (PBMCs) among patients with type 2 diabetes and is a biomarker of PBMC activation and inflammation. RESEARCH DESIGN AND METHODS We used a cross-sectional observational design to study a multi-racial/ethnic(More)
INTRODUCTION One in three people will be diagnosed with diabetes by 2050, and the proportion will likely be higher among Native Americans. Diabetes control is currently suboptimal in underserved populations despite a plethora of new therapies. Patient empowerment is a key determinant of diabetes control, but such empowerment can be difficult to achieve due(More)
Many cigarette smokers express a desire to quit smoking, but ~85% of cessation attempts fail. In our attempt to delineate genetic modulators of smoking persistence, we have earlier shown that a locus within an ~250 kb haplotype block spanning the 5' untranslated region region of insulin-degrading enzyme is associated with serum cotinine levels; the study's(More)
# These authors are Zuni community members and stakeholders. Abstract Introduction/Purpose: The Southwestern American Indian population carries a high prevalence of metabolic syndrome and obesity, placing this group at higher risk than the general population for developing early type 2 diabetes and cardiovascular disease , likely impacting overall lifespan.(More)
Diabetic peripheral neuropathy (DPN) is a complication of diabetes that leads to foot ulceration and amputations. Detection of DPN at an early stage is important for clinical management of the disease. This paper presents characterization of DPN subjects using an infrared imaging device and independent component analysis (ICA). Infrared video sequences are(More)