Learn More
In most cancers, transformation begins in a single cell in an epithelial cell sheet. However, it is not known what happens at the interface between non-transformed (normal) and transformed cells once the initial transformation has occurred. Using Madin-Darby canine kidney (MDCK) epithelial cells that express constitutively active, oncogenic Ras (RasV12) in(More)
During the initial stages of carcinogenesis, transformation events occur in a single cell within an epithelial monolayer. However, it remains unknown what happens at the interface between normal and transformed epithelial cells during this process. In Drosophila, it has been recently shown that normal and transformed cells compete with each other for(More)
In this paper we evaluate the utility of ergosterol as a measure of fungal biomass in temperate soils. We summarise published ®ndings and compare them with data from our own broad-scale assessment of the relationship between ergosterol and ATP in a range of temperate soils. Two hundred and ninety ®ve plots (three cores taken from each 10 10 m plot) in seven(More)
This paper presents work undertaken to integrate the future UK national Shibboleth infrastructure with the UK's National Grid Service (NGS). Our work, ShibGrid, provides both transparent authentication for portal based Grid access and a credential transformation service for users of other Grid access methods. The ShibGrid support for portal-based(More)
During tumor development, cells acquire multiple phenotypic changes upon misregulation of oncoproteins and tumor suppressor proteins. Hakai was originally identified as an E3 ubiquitin-ligase for the E-cadherin complex that regulates cell-cell contacts. Here, we present evidence that Hakai plays a crucial role in various cellular processes and(More)
In Drosophila, normal and transformed cells compete with each other for survival in a process called cell competition. However, it is not known whether comparable phenomena also occur in mammals. Scribble is a tumor suppressor protein in Drosophila and mammals. In this study we examine the interface between normal and Scribble-knockdown epithelial cells(More)
Previously our novel Shared Potential Field (SPF) method has been introduced and compared against a non-sharing control in both simulation and laboratory settings. In this paper, extended from a paper presented at the CIRAS2008 conference,we compare the SPF against an existing type of robot architecture, a hybrid robotic system. The SPF method is compared(More)
Who will be the grid users of tomorrow? We propose a categorisation of ‘future grid’ users into the following categories: Service End-User, Power User (with three distinct sub-types), Service Provider and Infrastructure Sysadmin. A further basic type could be argued as Third Party Beneficiary. This paper outlines the possible characteristics of these(More)
Previously our novel Shared Potential Field (SPF) method has been introduced and compared against a non-sharing control in both simulation and laboratory settings. In this paper, we compare the SPF against an existing type of robot architecture, a hybrid robotic system. The task given to the multi-robot systems is to traverse an unknown environment, in(More)
Using high-resolution Fourier-transform infrared absorbance and transmittance spectral data for ammonium sulfate (AMS), calcium carbonate (CAC), and ammonium nitrate (AMN), we made comparisons with previously published complex reactive-index data for AMS and CAC to infer experimental parameters to determine the imaginary refractive index for AMN in the(More)