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|A novel evolutionary computing method | quantum inspired genetic algorithms | is introduced, where concepts and principles of quantum mechanics are used to inform and inspire more eecient evolutionary computing methods. The basic terminology of quantum mechanics is introduced before a comparison is made between a classical genetic algorithm and a quantum(More)
primary neuronal cultures, as well as in lesioned animal models, have provided evidence that GDNF is a survival factor for embryonic midbrain dopaminergic neurons shown to promote the survival of cultured dopaminergic Bute Medical Building, St. Andrews and motor, but not peripheral, neurons (Milbrandt et al., United Kingdom 1998). 6 Deltagen, Incorporated(More)
Both researchers and practitioners need to know more about how laboratory treatment protocols translate to real-world practice settings and how clinical innovations can be systematically tested and communicated to a skeptical scientific community. The single-case time-series study is well suited to opening a productive discourse between practice and(More)
This paper seeks to draw a lesson for designing major reforms of corporate governance in the future. It recalls the key events leading to the recent seismic shift in corporate governance policies applicable to American public corporations, and identifies the four sources of policy changes – the Sarbanes-Oxley Act, new listing requirements, governance rating(More)
The paper identiies and demonstrates the feasibility of a novel computational paradigm which is inspired by the principles of quantum mechanics and quantum computing. A brief history of quantum computing and basic exposition of quantum mechanics are provided, followed by a detailed description of Shor's quantumàlgorithm' for factoring very large numbers. An(More)
Using mice double deficient for tumor necrosis factor (TNF) and lymphotoxin alpha (LTo0, we demonstrated that TNF and/or LToL are necessary for development of a normal splenic mi-croarchitecture and for isotype switch after immunization with sheep red blood cells (SRBC). In the present study, we extended these observations by determining which TNF receptor(More)
The importance of genetic predisposition, inflammation, and autoimmune mechanisms in the development of pulmonary arterial hypertension (PAH) is becoming increasingly clear. We hypothesized that the analysis of gene expression profiles from peripheral blood mononuclear cells would distinguish patients with PAH from normal volunteers. We also hypothesized(More)
Toll-like receptors orchestrate rapid local protective innate-immune responses to invading pathogens and optimize leukocyte priming of subsequent adaptive responses. Paradoxically, systemic excess of the TLR2 ligand, bacterial lipoprotein (BLP), suppresses peripheral inflammatory responses. Here, we demonstrate that this phenomenon is regulated via the(More)
Although used extensively in industry, regression testing is challenging from both a process management as well as a resource management perspective. In literature, proposed test case prioritization techniques assume a constant pool of test cases with non-changing coverage during the regression testing process, and therefore they work with a fixed,(More)
Any changes for maintenance or evolution purposes may break existing working features, or may violate the requirements established in the previous software releases. Regression testing is essential to avoid these problems, but it may be ended up with executing many time-consuming test cases. This paper tries to address prioritizing requirements-based(More)