RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood. Here we demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSCs), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo.… (More)
OBJECTIVE To describe the process of developing and validating the Canadian Association of Paediatric Health Centres Trigger Tool (CPTT). METHODS Five existing trigger tools were consolidated with duplicate triggers eliminated. After a risk analysis and modified Delphi process, the tool was reduced from 94 to 47 triggers. Feasibility of use was tested,… (More)
O wad some Power the giftie gie us To see oursels as ithers see us! (from " To A Louse " by Robert Burns, 1759–1796) is widely accepted that the desired improvements in patient safety require a change in the culture within healthcare (CPSI 2004; IOM 2000; NPSA 2004). The Institute of Medicine (IOM) report " To Err Is Human " concluded that " the status quo… (More)
1 We thank Gunnar Blix and Damien Weldon of First American CoreLogic (FACL) for their profound support at all stages of the project, as well as FRBNY and NYU for research support. We thank also for essential input and guidance. ABSTRACT Federal Housing Administration (FHA) insurance has doubled over the past two years and is projected to redouble to $1.5… (More)
BACKGROUND Keeping current with drug therapy information is challenging for health care practitioners. Technologies are often implemented to facilitate access to current and credible drug information sources. In the Canadian province of Nova Scotia, legislation was passed in 2002 to allow nurse practitioners (NPs) to practice collaboratively with physician… (More)
To study factors associated with anemia and its effect on survival in HIV-infected persons treated with modern combined antiretroviral therapy (cART), we characterized the prevalence of anemia in the Veterans Aging Cohort Study (VACS) and used a candidate gene approach to identify proinflammatory gene single nucleotide polymorphisms (SNPs) associated with… (More)
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The relationship between obstetrician attitudes and patient outcomes from intrapartum care was examined. Obstetrician attitudes were assessed utilizing a newly-designed pilot 35-item obstetrician attitude questionnaire (OAQ). Twelve obstetricians completed the OAQ, who provided intra-partum care to 4,149 women. Outcome measures included delivery mode and… (More)