Mark M. Davis

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For a service delivery system to produce optimal solutions to service-related business problems, it must be based on an approach that involves many of the traditional functional areas in an organization. Unfortunately, most business school curricula mirror the older traditional organizational structure that dominated businesses throughout most of the(More)
MOTIVATION Subcellular protein localization data are critical to the quantitative understanding of cellular function and regulation. Such data are acquired via observation and quantitative analysis of fluorescently labeled proteins in living cells. Differentiation of labeled protein from cellular artifacts remains an obstacle to accurate quantification. We(More)
The immune system of higher organisms is, by any standard, complex. To date, using reductionist techniques, immunologists have elucidated many of the basic principles of how the immune system functions, yet our understanding is still far from complete. In an era of high throughput measurements, it is already clear that the scientific knowledge we have(More)
The blood gene expression signatures are used as biomarkers for immunological and non- immunological diseases. Therefore, it is important to understand the variation in blood gene expression patterns and the factors (heritable/non-heritable) that underlie this variation. In this paper, we study the relationship between drug effects on the one hand, and(More)
Studies have shown a large number of immune related diseases, in particular auto-immune diseases, to have a genetic component. The immune system is dependent on the functionality of a multitude of components, key factors of which are the different immune cell-type subsets and the cytokines to which they respond to or secrete. However, the abundance of(More)
Single-particle tracking provides a powerful technique for measuring dynamic cellular processes on the level of individual molecules. Much recent work has been devoted to using single particle tracking to measure long-range movement of particles on the cell surface, including methods for automated localization and tracking of particles [1-3]. However, most(More)
Fluorescence microscopy of labeled proteins yields a wealth of data on cell signaling processes. However, systems for quantitative analysis of such data have lagged behind the recent progress in data acquisition technology. As cellular protein redistribution plays a key role in proximal signaling and the establishment of cell polarity, quantitative(More)
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