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Introduction Anatomical Connectivity Mapping (ACM) based on diffusion MRI generates a scalar map that reflects the connectivity of each voxel with the rest of the brain [1, 2]. The value of an ACM voxel reflects white mater integrity both locally and globally and the ACM is therefore able to reveal effects not seen with traditional diffusion maps such as(More)
Multiple sclerosis (MS) damages central white matter pathways which has considerable impact on disease-related disability. To identify disease-related alterations in anatomical connectivity, 34 patients (19 with relapsing remitting MS (RR-MS), 15 with secondary progressive MS (SP-MS) and 20 healthy subjects underwent diffusion magnetic resonance imaging(More)
OBJECTIVE Natalizumab inhibits the migration of systemic immune cells to the CNS and may be beneficial in progressive multiple sclerosis (MS). The objective of the study was to examine the effects of natalizumab in progressive MS. METHODS In an open-label phase 2A study, 24 patients with progressive MS were included to receive natalizumab treatment for 60(More)
BACKGROUND There is a large unmet need for treatments for patients with progressive multiple sclerosis (MS). Phase 2 studies with cerebrospinal fluid (CSF) biomarker outcomes may be well suited for the initial evaluation of efficacious treatments. OBJECTIVE To evaluate the effect of monthly oral methylprednisolone pulse treatment on intrathecal(More)
One of the problems arising in radiotherapy planning is the quality of CT planning data. In the following attention is giving to the cone-beam scanning geometry where reconstruction of a 3D volume based on 2D projections, using the classic Feldkamp-Davis-Kress (FDK) algorithm requires a large number of projections to be adequate. Since the patients are(More)
This paper introduces a novel approach to modelling of volumetric cardiac magnetic resonance imaging (MRI) with simultaneous resolution of cardiac and respiratory motion. The major challenge is that the inherent slow nature of MRI prevents obtaining real-time volumetric images of the heart with sufficient spatial and temporal resolution. To overcome this(More)
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