Mark Liebow

Learn More
Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls.(More)
  • Jack A Ginsburg, Robert B Doherty, J Fred Ralston, Naomi Senkeeto, Molly Cooke, Charles Cutler +13 others
  • 2008
This position paper concerns improving health care in the United States. Unlike previous highly focused policy papers by the American College of Physicians, this article takes a comprehensive approach to improving access, quality, and efficiency of care. The first part describes health care in the United States. The second compares it with health care in(More)
Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising(More)
It has been hypothesized that vitamin D mediates the inverse relationship between sun exposure and non-Hodgkin lymphoma (NHL) risk reported in several recent studies. We evaluated the association of self-reported sun exposure at ages <13, 13–21, 22–40, and 41+ years and 19 single nucleotide polymorphisms (SNPs) from 4 candidate genes relevant to vitamin D(More)
  • Abraham Peedicayil, Robert A. Vierkant, Lynn C. Hartmann, Brooke L. Fridley, Zachary S. Fredericksen, Kristin L. White +17 others
  • 2010
BACKGROUND We previously identified a panel of genes associated with outcome of ovarian cancer. The purpose of the current study was to assess whether variants in these genes correlated with ovarian cancer risk. METHODS AND FINDINGS Women with and without invasive ovarian cancer (749 cases, 1,041 controls) were genotyped at 136 single nucleotide(More)
Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases(More)
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk.(More)
Metrics typically used to report the performance of an early warning score (EWS), such as the area under the receiver operator characteristic curve or C-statistic, are not useful for pre-implementation analyses. Because physiological deterioration has an extremely low prevalence of 0.02 per patient-day, these metrics can be misleading. We discuss the(More)
  • Jon C Tilburt, Matthew K Wynia, Victor M Montori, Bjorg Thorsteinsdottir, Jason S Egginton, Robert D Sheeler +3 others
  • 2014
OBJECTIVE To assess US physicians' attitudes towards using shared decision-making (SDM) to achieve cost containment. DESIGN Cross-sectional mailed survey. SETTING US medical practice. PARTICIPANTS 3897 physicians were randomly selected from the AMA Physician Masterfile. Of these, 2556 completed the survey. MAIN OUTCOME MEASURES Level of enthusiasm(More)