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OBJECTIVES We developed perception-based spike detection and clustering algorithms. METHODS The detection algorithm employs a novel, multiple monotonic neural network (MMNN). It is tested on two short-duration EEG databases containing 2400 spikes from 50 epilepsy patients and 10 control subjects. Previous studies are compared for database difficulty and(More)
OBJECTIVE The aim of this study is to evaluate an improved seizure detection algorithm and to compare with two other algorithms and human experts. METHODS 672 seizures from 426 epilepsy patients were examined with the (new) Reveal algorithm which utilizes 3 methods, novel in their application to seizure detection: Matching Pursuit, small neural(More)
PURPOSE To report on the use of near-infrared spectroscopy (NIRS) to examine the changes in cerebral oxygenation in the periictal period in patients with seizures. METHODS Cerebral hemoglobin oxygen availability was monitored continuously and noninvasively with NIRS in three patients (one in the pediatric intensive care unit (ICU) and two in(More)
There is strong evidence for a genetic contribution to epilepsy, but it is commonly assumed that this genetic contribution is limited to 'generalized' epilepsies, and that most forms of 'partial' epilepsy are nongenetic. In a linkage analysis of a single family containing 11 affected individuals, we obtained strong evidence for localization of a gene for(More)
Methods for standardized classification of epileptic seizures are important for both clinical practice and epidemiologic research. In this study, we developed a strategy for standardized classification using a semistructured telephone interview and operational diagnostic criteria. We interviewed 1,957 adults with epilepsy ascertained from voluntary(More)
PURPOSE We wished to assess the reliability of the International League Against Epilepsy (ILAE) seizure classification system applied to infantile seizures and to test a proposed new classification. METHODS We first analyzed 39 seizures in 20 infants (aged 1-26 months) recorded with simultaneous closed-circuit television and EEG (CCTV/EEG). EEGs and(More)
Recent data indicate that the incidence and prevalence of seizures and epilepsy rise substantially in the elderly. Little well-founded information is available on which to base treatment decisions. This article discusses cause, diagnostic evaluation, and antiepileptic drug pharmacology. Tentative treatment suggestions are offered, emphasizing the limits of(More)
Continuous EEG monitoring (CEEG) is a powerful tool for evaluating cerebral function in obtunded and comatose critically ill patients. The ongoing analysis of CEEG data is a major task because of the volume of data generated during monitoring and the need for near real-time interpretation of a patient's EEG patterns. Advances in digital EEG data(More)
OBJECTIVE To evaluate an automated seizure detection (ASD) algorithm in EEGs with periodic and other challenging patterns. METHODS Selected EEGs recorded in patients over 1year old were classified into four groups: A. Periodic lateralized epileptiform discharges (PLEDs) with intermixed electrical seizures. B. PLEDs without seizures. C. Electrical seizures(More)