Mark L. MacDonald

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From the foregoing discussion of the nutritional requirements and some of the metabolic anomalies of the cat, it is clear that the cat is adapted to eating a carnivorous diet. It may, however, have less capability than omnivores and herbivores to adapt to wide ranges in dietary composition. For example, the lack of ability to synthesize sufficient vitamin A(More)
To determine the essential fatty acid (EFA) requirements of the cat, specific pathogen-free kittens were fed either a linoleate-deficient diet or one of two diets containing 5% safflower seed oil (SSO) with or without 0.2% tuna oil. The diets were fed for 82-101 weeks beginning at 3 months of age. The results showed that linoleate is an essential fatty acid(More)
The inability of the cat to convert significant quantities of linoleate [18:2(9,12)] to arachidonate [20:4(5,8,11,14]) in the liver makes the cat a useful model for studying the specific physiological roles of these two fatty acids. In these studies, cats were fed purified diets that were either deficient in essential fatty acids (EFAs) or that provided(More)
The pathologic changes of essential fatty acid (EFA) deficiency were studied in specific-pathogen-free, domestic shorthair cats which were fed purified diets for 1.5 to 2.5 years. Cats fed an EFA-deficient diet exhibited signs of deficiency: severe fatty degeneration of the liver, excessive fat in the kidneys, dystrophic mineralization of the adrenal(More)
Because the cat lacks the ability to synthesize a significant amount of arachidonate from linoleate in the liver, arachidonate is a dietary essential. We studied the effects of essential fatty acid deficiency on the aggregation of cat platelets. Cat platelets aggregated in response to ADP, collagen, arachidonate and epinephrine. Aggregation was impaired in(More)
Young, specific-pathogen-free cats were fed purified diets containing different sources of fat. Food intake was depressed and cats lost weight when the diet contained either hydrogenated coconut oil (HCO) or medium-chain triglycerides (MCT). With an MCT preparation enriched in 8:0 (MCT8), cats would not eat after first tasting the diet. When cats were(More)
In this paper we determine all possible cohomological invariants of Aut(J)-torsors in Galois cohomology with mod 2 coefficients (characteristic of the base field not 2), for J a split central simple Jordan algebra of odd degree n ≥ 3. This has already been done for J of orthogonal and exceptional type, and we extend these results to unitary and symplectic(More)
This paper gives a new upper bound for the essential dimension and the essential 2-dimension of the split simply connected group of type E7 over a field of characteristic not 2 or 3. In particular, ed(E7) ≤ 29, and ed(E7; 2) ≤ 27. The essential dimension of an algebraic group G is a numerical invariant which measures the complexity of its G-torsors. The(More)
This paper shows that the number of independent parameters required to describe an Albert algebra up to isomorphism is at most 7. In other words, the essential dimension of the split group of type F4 over a field of characteristic not 2 or 3 satisfies ed(F4) ≤ 7. This is achieved by reducing the structural group from the full 52-dimensional automorphism(More)