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In recent years, the use of adaptive design methods in clinical research and development based on accrued data has become very popular due to its flexibility and efficiency. Based on adaptations applied, adaptive designs can be classified into three categories: prospective, concurrent (ad hoc), and retrospective adaptive designs. An adaptive design allows(More)
Mobile phone services based on the location of a user have increased in popularity and importance, particularly with the proliferation of feature-rich smartphones. One major obstacle to the widespread use of location-based services is the limited battery life of these mobile devices and the high power costs of many existing approaches. We demonstrate the(More)
Numerous studies have demonstrated the role of the central nervous system in immunomodulation. beta-Endorphin, a neuropeptide that is released along with adrenocorticotropin by the pituitary in response to stress, has been shown to have various effects on immune function, although these effects are dependent on dose, animal model, and immune cell tested.(More)
DNA was isolated from the hippocampal and from the somatosensory cortex of 13 humans (at autopsy). In both the cortex and hippocampus, the loss of ribosomal DNA (rDNA), as measured through hybridization in the liquid phase, approximates about 0.9% per year. The r value for somatosensory cortex was about -0.7 and that for the hippocampus was about -0.91. The(More)
DNA obtained from 29 male humans at autopsy was hybridized in liquid phase with tritium-labelled 18 and 28S ribosomal RNA (rRNA) in order to determine whether a change in the dosage in rDNA, which codes for rRNA, occurs during human aging. The individuals ranged in age from 3 months to 76 years. It was found that the amount of rDNA hybridizable per 260 nm(More)
We present an indoor wireless localization system that is capable of room-level localization based solely on 802.11 network signal strengths and user-supplied training data. Our system naturally gathers dense data in places that users frequent while ignoring unvisited areas. By utilizing users, we create a comprehensive localization system that requires(More)