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PURPOSE To evaluate prospectively the effectiveness of epoetin alfa as an adjunct to chemotherapy in patients with cancer based on changes in quality-of-life parameters and hemoglobin levels, and to correlate these changes with antitumor response. PATIENTS AND METHODS Two thousand three hundred seventy patients with nonmyeloid malignancies who received(More)
PURPOSE To investigate the tolerability, pharmacokinetics, and antitumor activity of the oral, selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 in patients with solid malignant tumors. PATIENTS AND METHODS This was an open, phase I, escalating multiple-dose tolerability and pharmacokinetic trial. ZD1839 was administered once(More)
PURPOSE The aim of this study was to quantify the effects of small plus focal errors on the quality of vision of wearers who habitually wear either no correction, or a low powered, distance only correction. METHODS Patients wore spectacles with small errors deliberately included for a 2-day trial wear period; a short subjective questionnaire, and some(More)
Many cancer patients experience persistent fatigue after the completion of chemotherapy. A previous single-arm study provided evidence for an effect of acupuncture in this population. We conducted a randomized controlled trial to determine whether acupuncture reduces post-chemotherapy chronic fatigue more effectively than sham acupuncture. Cancer patients(More)
Kaposi's sarcoma, a multicentric malignant neoplasm, occurs in certain geographic areas in the world. It is most common in Equatorial Africa and Eastern Europe. The annual incidence of Kaposi's sarcoma in the United States is between 0.021 and 0.061 per 100,000 persons. The appearance of an outbreak of Kaposi's sarcoma in young homosexual men in New York(More)
Previous pharmacological and clinical data have suggested that it is possible to increase significantly the dose of “active” cisplatin delivered systemically by the simultaneous administration of intravenous sodium thiosulfate. In order to define more critically the toxicity and potential efficacy of this therapeutic approach, 36 patients with a variety of(More)
To test that the Humphrey Lens Analyzer can be used validly to measure off-axis powers of progressive addition lenses of low distance power, we made measurements of a plano distance progressive power lens with both a conventional focimeter and the Humphrey Lens Analyzer. The use of the Humphrey Lens Analyzer in two modes, one in which the lens rotated about(More)
Automated focimeters can be used to make quick, precise measurements of off-axis power and prismatic effects corresponding to an eye rotating behind a spectacle lens. An automated focimeter, the Humphrey Lens Analyzer, was assessed in this regard. The Humphrey Lens Analyzer can be used to give a valid measure of off-axis power of lenses with low power, but(More)