Mark Karpenko

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This paper is aimed at the characterization of beta-III-tubulin, MAP2 and doublecortin, the proteins which participate in the organization, stabilization and function of the microtubules of nerve cell cytoskeleton. Due to the structural and functional features, these proteins may be regarded as differentiation markers, associated with neurogenesis and as(More)
Morphological changes in the spinal cord were studied at the peak of development of experimental allergic encephalomyelitis in rats with different levels of disease symptoms. Light microscopy and immunohistochemical study methods were used. The distribution of proliferating cell nuclear antigen (PCNA) was studied, along with the distributions of the(More)
The Ca2+-dependent calpain system of intracellular proteases is involved in regulating a multitude of physiological body functions. However, hyperactivation of calpains in cells is observed during the development of a number of responses, and this leads to impairment to the functioning of vitally important physiological systems. We report here our use of a(More)
In this paper, reinforcement learning is applied to coordinate, in a decentralized fashion, the motions of a pair of hydraulic actuators whose task is to firmly hold and move an object along a specified trajectory under conventional position control. The learning goal is to reduce the interaction forces acting on the object that arise due to inevitable(More)
This paper documents the development and experimental evaluation of a practical nonlinear position controller for a typical industrial pneumatic actuator that gives good performance for both regulating and reference tracking tasks. The system is comprised of a low-cost 5port proportional valve with flow deadband and a double-rod actuator exhibiting(More)
Quantitative feedback theory (QFT) is applied towards the design of a simple and effective position controller for a typical low-cost industrial pneumatic actuator with a 5-port three-way control valve, that is subject to disturbing forces. A simple fixed-gain proportional-integral control law with dynamic pressure feedback is synthesized to guarantee the(More)