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  • Cesar G Fraga, Mark K. Shigenaga, Ji Woo Park, Paolo Degan, Bruce N. Ames
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 1990 (First Publication: 1 June 1990)
  • Oxidative damage to DNA is shown to be extensive and could be a major cause of the physiological changes associated with aging and the degenerative diseases related to aging such as cancer. TheContinue Reading
  • Cesar G Fraga, Paul A. Motchnik, Mark K. Shigenaga, H J Helbock, Robert A. Jacob, Bruce N. Ames
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1991 (First Publication: 15 December 1991)
  • Damage to the DNA of germ cells can lead to mutation, which may result in birth defects, genetic diseases, and cancer. The very high endogenous rate of oxidative DNA damage and the importance ofContinue Reading
  • Jong Yi Park, Mark K. Shigenaga, Bruce N. Ames
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1996 (First Publication: 19 March 1996)
  • Induction of cytochrome P4501A1 (CYP1A1) in the hepatoma Hepa1c1c7 cell line results in an elevation in the excretion rate of 8-oxoguanine (oxo8Gua), a biomarker of oxidative DNA damage and the majorContinue Reading
  • Maria B. Kadiiska, Beth C. Gladen, +31 authors Jeffrey C. Barrett
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 2005 (First Publication: 1 March 2005)
  • Oxidation products of lipids, proteins, and DNA in the blood, plasma, and urine of rats were measured as part of a comprehensive, multilaboratory validation study searching for noninvasive biomarkersContinue Reading
  • Jingjing Liu, Xiang-dong Wang, Mark K. Shigenaga, Huat Chye Yeo, Akitane Mori, Bruce N. Ames
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 1996 (First Publication: 1 November 1996)
  • Immobilization stress of male Sprague-Dawley rats induces oxidative damage to lipid, protein, and DNA in the brain. Significant increases in lipid peroxidation were found in the cerebral cortex,Continue Reading