Mark Jyn-Huey Lim

Learn More
OBJECTIVES:Some patients with primary biliary cirrhosis (PBC) have antinuclear antibodies (ANAs). These ANAs include the “multiple nuclear dots” (MND) staining pattern, targeting promyelocytic leukemia protein (PML) nuclear body (NB) components, such as “speckled 100-kD” protein (Sp100) and PML. A new PML NB protein, designated as Sp140, was identified(More)
Proteome microarrays hold great promise for various biotechnological and biomedical applications, including mapping protein-protein interactions, drug discovery, and biomarker discovery. However, the need to express, purify, and print thousands of functional proteins at high density on a microarray substrate presents challenges that limit their widespread(More)
Nonsense or frameshift mutations, which result in a truncated gene product, are prevalent in a variety of disease-related genes, including APC (implicated in colorectal cancer), BRCA1 and BRCA2 (breast and ovarian cancer), PKD1 (polycystic kidney disease), NF1 and NF2 (neurofibromatosis), and DMD (Duchenne muscular dystrophy). Such chain-truncating(More)
Colorectal cancer (CRC) is the second leading cause of cancer deaths in the US and Western world. Despite increased screening and advances in treatment, the mortality rate (ca. 50,000/year) and high national health-care burden for CRC are likely to remain high unless an effective non-invasive screening test for CRC is instituted for a large segment of the(More)
Within the area of criminal and terrorist social network analysis, there is little research being done on analysing the communication behavior of criminal and terrorist groups. In this paper, we describe the development of a conceptual simulation model of the e-mail system, which is based on the use of personality trait dimensions to model the e-mail(More)
E-mail is one of the most popular and widely used form of electronic communication used today. The patterns in the social interactions or contacts between people by email can be analysed using social network analysis and user behaviour analysis. In this paper we provide a review of the work related to the areas of dynamic modelling and link prediction of(More)
E-mail traffic analysis is an area of work that focuses on extracting information about the behaviour of e-mail users based on the sender, receiver, and date/time information taken from the header section of e-mail messages. Such work has applications for law enforcement where investigators and analysts require techniques to assist them with finding unusual(More)
RATIONALE Rapidly performing global proteomic screens is an important goal in the post-genomic era. Correlated matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and fluorescent imaging of photocleavable peptide-coded random bead-arrays was evaluated as a critical step in a new method for proteomic screening that combines many of the(More)