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Polyfluorinated compounds: past, present, and future.
The utility of these compounds seems to ensure their continued use in one form or another for the foreseeable future, presenting a long-term challenge to scientists, industry leaders, and public health officials worldwide. Expand
Effects of perfluorooctanoic acid exposure during pregnancy in the mouse.
Data indicate maternal and developmental toxicity of PFOA in the mouse, leading to early pregnancy loss, compromised postnatal survival, delays in general growth and development, and sex-specific alterations in pubertal maturation. Expand
Perfluorooctanoic acid induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator activated receptor-alpha.
  • B. Abbott, C. Wolf, +7 authors C. Lau
  • Biology, Medicine
  • Toxicological sciences : an official journal of…
  • 1 August 2007
Early pregnancy loss was independent of PPARalpha expression and PFOA induced postnatal lethality and expression of one copy of the gene was sufficient to mediate this effect, although other mechanisms may contribute. Expand
Perfluorooctanoic Acid–Induced Immunomodulation in Adult C57BL/6J or C57BL/6N Female Mice
IgM antibodies were suppressed after PFOA exposure, and the margin of exposure for reduced IgM antibody synthesis was approximately 150 for highly exposed human populations. Expand
Comparative Hepatic Effects of Perfluorooctanoic Acid and WY 14,643 in PPAR-α Knockout and Wild-type Mice
It is suggested that PPAR-α is required for WY- and PFOA-induced cellular alterations in WT mouse liver, and Hepatic enlargement observed in KO mice may be due to an accumulation of cytoplasmic vacuoles that contain P FOA. Expand
Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring.
Findings suggest that in addition to gestational exposure, abnormal lactational development of dams may play a role in early growth retardation of developmentally exposed offspring. Expand
Developmental toxicity of perfluorooctane sulfonate (PFOS) is not dependent on expression of peroxisome proliferator activated receptor-alpha (PPAR alpha) in the mouse.
It is concluded that PFOS-induced neonatal lethality and delayed eye opening are not dependent on activation of PPAR alpha. Expand
Perfluorinated compounds in the Cape Fear Drainage Basin in North Carolina.
A new method was developed for the analysis of 10 target PFCs and its performance was examined in a systematic evaluation of surface water in the Cape Fear River Basin in North Carolina, finding the lowest concentrations are found in the smallest tributaries while the highest levels were found in middle reaches of the Drainage Basin. Expand
Perfluorinated compounds in whole fish homogenates from the Ohio, Missouri, and Upper Mississippi Rivers, USA.
The 10 samples with PFOS concentrations above 200 ng/g were broadly scattered across all three rivers, providing evidence of the widespread presence of this compound in these US waterways. Expand
Legacy and Emerging Perfluoroalkyl Substances Are Important Drinking Water Contaminants in the Cape Fear River Watershed of North Carolina
Long-chain per- and polyfluoroalkyl substances (PFASs) are being replaced by short-chain PFASs and fluorinated alternatives. For ten legacy PFASs and seven recently discovered perfluoroalkyl etherExpand