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BACKGROUND Polycyclic aromatic hydrocarbons (PAHs) are abundant and widespread environmental chemicals. They are produced naturally and through man-made processes, and they are common in organic media, including petroleum. Several PAHs are toxic, and a subset exhibit carcinogenic activity. PAHs represent a range of chemical structures based on two or more(More)
To evaluate the role of cGMP in vertebrate rod photoreceptors, two extracellular effectors of cGMP were used (calcium and buffer), and both cGMP content and electrophysiological responses were measured. In the dark when the cGMP content was reduced by 80%, electrophysiological effects mimicking a weak background light were observed. Continuous illumination,(More)
BACKGROUND The Deepwater Horizon oil spill of 2010 prompted concern about health risks among seafood consumers exposed to polycyclic aromatic hydrocarbons (PAHs) via consumption of contaminated seafood. OBJECTIVE The objective of this study was to conduct population-specific probabilistic health risk assessments based on consumption of locally harvested(More)
The immunocytochemical expression of laminin and fibronectin by non-transformed liver epithelial cells and by transformed cells derived from the same cell line, TRL1215, was examined in ethionine-transformed cells (ETC), untreated control cells at the same high passage level (HPC), and untreated, low passage cells (LPC). At confluence, a divergent(More)
In earlier studies, we have characterized a newly developed cell line derived from the renal proximal tubule epithelial cells (RPTEC) of a healthy human male donor in order to provide an improved in vitro model with which to investigate human diseases, such as cancer, that may be promoted by toxicant exposure. The RPTEC/TERT1 cell line has been immortalized(More)
The electrophysiological characteristics of norpAH52, a temperature sensitive phototransduction mutant of Drosophila melanogaster, were studied in vivo. Upon raising the environmental temperature to 33-37 degrees C, mutant flies exhibited time-dependent changes in photoresponses. Initial observations were losses in responsiveness at low light intensities(More)
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