Learn More
We present PolyLens, a new collaborative filtering recommender system designed to recommend items for groups of users, rather than for individuals. A group recommender is more appropriate and useful for domains in which several people participate in a single activity, as is often the case with movies and restaurants. We present an analysis of the primary(More)
This short paper reports on work in progress related to applying data partitioning/clustering algorithms to ratings data in collaborative filtering. We use existing data partitioning and clustering algorithms to partition the set of items based on user rating data. Predictions are then computed independently within each partition. Ideally, partitioning will(More)
Intrinsic radiosensitivity is an important factor underlying radiotherapy response, but there is no method for its routine assessment in human tumours. Gene signatures are currently being derived and some were previously generated by expression profiling the NCI-60 cell line panel. It was hypothesised that focusing on more homogeneous tumour types would be(More)
Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, has been found to have therapeutic potential for treating cancers associated with impaired DNA repair capabilities, particularly those with deficiencies in the homologous recombination repair (HRR) pathway. Histone deacetylases (HDACs) are important for enabling functional HRR of DNA by regulating(More)
BRCA1 protein measurement has previously been evaluated as a potential diagnostic marker without reaching a conclusive recommendation. In this study, we applied current best practice in antibody validation to further characterize MS110, a widely used antibody targeting BRCA1. Antibody specificity was investigated using different biochemical validation(More)
Blanket peat catchments are important biodiversity refugia. Key pressures on peatland catchment water bodies include artificial drainage, forestry, over-grazing, wind farm development and climate change, and assessment of these pressures requires sensitive monitoring programmes. This study, undertaken in two neighbouring blanket peat catchments, examined(More)
PARP-1 is a critical enzyme in the repair of DNA strand breaks. Inhibition of PARP-1 increases the effectiveness of radiation in killing tumor cells. However, although the mechanism(s) are well understood for these radiosensitizing effects in vitro, the underlying mechanism(s) in vivo are less clear. Nicotinamide, a drug structurally related to the first(More)
Disclosure of potential conflicts of interest: Mark J.O'Connor is currently an employee at AstraZeneca, which has Olaparib running in clinical trials. All other authors declare no potential conflicts of interest. Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. This functional assay will facilitate(More)
Purpose: Most patients with ovarian carcinomas succumb to their disease and there is a critical need for improved therapeutic approaches. Carcinomas arising in BRCA mutation carriers display defective DNA double-strand break repair that can be therapeutically exploited by inhibition of PARP-1, a key enzyme in the repair of DNA single-strand breaks, creating(More)
This study aimed to determine which methods of remote symptom assessment cancer outpatients would be comfortable using, including those involving information technology, and whether this varied with age and gender. A questionnaire survey of 477 outpatients attending the Edinburgh Cancer Centre in Edinburgh, UK. Most patients reported that they would not(More)