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The current method of grading prostate cancer on histology uses the Gleason system, which describes five increasingly malignant stages of cancer according to qualitative analysis of tissue architecture. The Gleason grading system has been shown to suffer from interand intra-observer variability. In this paper we present a new method for automated and(More)
This paper uses a combined experimental and theoretical approach to gain unique insight into gene delivery. We report the synthesis and investigation of a new family of second-generation dendrons with four triamine surface ligands capable of binding to DNA, degradable aliphatic-ester dendritic scaffolds, and hydrophobic units at their focal points. Dendron(More)
The outcomes of treatment of physical illnesses are strongly affected by the presence of schizophrenia. We aimed to quantify the clinical course of schizophrenic breast cancer patients who were eligible for adjuvant chemotherapy to determine whether patients with this mental illness receive appropriate treatment for this physical illness. We searched the(More)
Mergers and acquisitions are important business strategy for growth. Many mergers and acquisitions have failed, however, due to a mismatch between strategic, organizational, and increasingly, information systems factors. Given that a large number of enterprise systems have been deployed in the last decade, their integration post merger is crucial to(More)
Non-viral gene delivery vehicles such as polyethylenimine and polyamidoamine dendrimer effectively condense plasmid DNA, facilitate endocytosis, and deliver nucleic acid cargo to the nucleus in vitro. Better understanding of intracellular trafficking mechanisms involved in polymeric gene delivery is a prerequisite to clinical application. This study(More)
BACKGROUND Schizophrenia affects approximately 1% of subjects in all populations studied thus far. We sought to evaluate how patients with schizophrenia who are later diagnosed with breast cancer fare when adjuvant radiation therapy (ART) is clinically indicated. METHODS We searched patient treatment file, the national inpatient computer database of the(More)
The measurement of systems success is important to any research on information systems. A research study typically uses several dependent measures as surrogates for systems success. These dependent measures are generally treated as outcome variables which, as a group, vary as a function of certain independent variables. Recently, a process perspective has(More)
Breast cancer brain metastasis (BCBM) is associated with high morbidity and mortality. Patients with breast cancer risk factors associated with rapid development of BCBM could potentially benefit from early brain metastasis screening. We retrospectively reviewed all BCBM patients treated with brain radiotherapy at our institution from 1997 to 2015. Interval(More)
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