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1. The effect of pretreatment with pertussis toxin has been studied on responses to muscarinic agonists in guinea-pig atria and smooth muscle in vitro. 2. 48 h after a single intravenous injection of pertussis toxin (3.2-100 micrograms.kg-1), muscarinic receptor-mediated negative inotropic responses in the atria were inhibited in a dose-dependent manner,(More)
Pretreatment with pertussin toxin was shown to inhibit selectively muscarinic responses in the atria, but have no effect on responses in the ileum. The converse was true when the animals were pretreated with lithium. These data are consistent with the hypothesis that muscarinic receptors in the atria are coupled to an inhibition of adenylate cyclase, whilst(More)
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