Mark Holly

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A compact hand-held heated fluorometric instrument for performing real-time isothermal nucleic acid amplification and detection is described. The optoelectronic instrument combines a Printed Circuit Board/Micro Electro Mechanical Systems (PCB/MEMS) reaction detection/chamber containing an integrated resistive heater with attached miniature LED light source(More)
A model of calcium distribution in the sarcomere during activation of contraction was developed. It allows for diffusion and binding of calcium ions to various sarcoplasmic binding sites in the three dimensional spatial coordinate system. The model was used to analyze the influence of kinetic characteristic of binding processes on the temporal and spatial(More)
The review summarizes recent knowledge concerning regulatory mechanisms of skeletal muscle cell contraction. Calcium ions are the essential mediator of these processes. Their primary function is signal transmission from the sarcoplasmic reticulum to contractile proteins. A large variety of methods is available for the investigation of such complex molecular(More)
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