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Parity encoded redundant disk arrays provide highly reliable, cost effective secondary storage with high performance for read accesses and large write accesses. Their performance on small writes, however, is much worse than mirrored disks—the traditional, highly reliable, but expensive organization for secondary storage. Unfortunately, small writes(More)
1 Abstract The performance of traditional RAID Level 5 arrays is, for many applications, unacceptably poor while one of its constituent disks is non-functional. This paper describes and evaluates mechanisms by which this disk array failure-recovery performance can be improved. The two key issues addressed are the data layout, the mapping by which data and(More)
We describe and evaluate a strategy for declustering the parity encoding in a redundant disk array. This declustered parity organization balances cost against data reliability and performance during failure recovery. It is targeted at highly-available parity-based arrays for use in continuous-operation systems. It improves on standard parity organizations(More)
The complexity of advanced disk array architectures makes accurate representation necessary, arduous, and error-prone. In this paper, we present RAIDframe, an array framework that separates architectural policy from execution mechanism. RAIDframe facilitations rapid prototyping of new RAID architec-tures by localizing modifications and providing libraries(More)
The authors describe and evaluate two algorithms for performing online failure recovery (data reconstruction) in redundant disk arrays. An implementation of disk-oriented reconstruction, a data recovery algorithm that allows the reconstruction process to absorb essentially all the disk bandwidth not consumed by the user processes, is presented, and this(More)
We developed a murine model of CNS disease to obtain a better understanding of the pathogenesis of CNS involvement in pre-B-cell acute lymphoblastic leukemia (ALL). Semiquantitative proteomic discovery-based approaches identified unique expression of asparaginyl endopeptidase (AEP), intercellular adhesion molecule 1 (ICAM1), and ras-related C3 botulinum(More)
Chimeric Ag receptors (CARs) expressed in T cells permit the redirected lysis of tumor cells in an MHC-unrestricted manner. In the Jurkat T cell model system, expression of a carcinoembryonic Ag-specific CD3zeta CAR (MFEzeta) resulted in an increased sensitivity of the transduced Jurkat cell to generate cytokines when stimulated through the endogenous TCR(More)