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BACKGROUND Cockroach allergy is a key contributor to asthma morbidity in children living in urban environments. OBJECTIVE We sought to document immune responses to cockroach allergen and provide direction for the development of immunotherapy for cockroach allergy. METHODS Four pilot studies were conducted: (1) an open-label study to assess the safety of(More)
BACKGROUND Allergic rhinitis (AR) affects up to 80% of children with asthma and increases asthma severity. Thymic stromal lymphopoietin (TSLP) is a key mediator of allergic inflammation. The role of the TSLP gene (TSLP) in the pathogenesis of AR has not been studied. OBJECTIVE To test for associations between variants in TSLP, TSLP-related genes, and AR(More)
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