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We analyzed the clinical phenotype and determined the recurrence risks to relatives of patients with T14484C Leber's hereditary optic neuropathy (LHON). LHON is a maternally inherited optic neuropathy that primarily affects adolescent males. It is usually associated with one of three mtDNA mutations: G3460A, G11778A, or T14484C. Definition of recurrence(More)
Wistar rats learned to withhold consumption of a target solution when morphine preceded presentation of the target solution and lithium chloride (LiCl) and to consume the same target solution when saline preceded the presentation of the solution. After this serial feature discrimination training, morphine did not block the formation of a Pavlovian(More)
OBJECTIVE To report the clinical manifestations and functional aspects of Tuberous Sclerosis Complex (TSC), resulting from Codon 905 mutations in TSC2 gene. METHODS We performed a detailed study of the TSC phenotype and genotype in a large French-Canadian kindred (Family A). Subsequently, clinical and molecular data on 18 additional TSC families with(More)
Since the observation by Bridges of a few mosaics containing haploid tissue in Drosophila, specimens supposedly haploid have rarely been found. A technique for the easy production of haploid animals or tissues could have important applications. We have now successfully designed such a technique by the production of chimaeras obtained by transplantation of(More)
A scheme to achieve a wideband linearized silicon Mach-Zehnder (MZ) modulator is proposed. The modulator consists of a single MZ interferometer with identical reverse-biased silicon diode phase shifters in both arms, driven in a push-pull configuration. It is shown that the 3rd order nonlinearity of the modulator can be eliminated by canceling the(More)
A 27-year-old man developed a persistent bitemporal hemianopia after severe head trauma sustained in a high-speed motor vehicle accident. The initial brain MRI revealed hemorrhagic contusion of the optic chiasm. A brain MRI performed 4 weeks later demonstrated complete chiasmal transection, a phenomenon rarely documented with imaging.
We assessed visual function after recovery from optic neuritis in 15 consecutive patients using five objective tests: colour vision testing with Ishihara colour plates and with D15 colour desaturated spots, Humphrey automated perimetry, contrast acuity testing with Regan letter charts and testing of visual evoked response (VER). Recovery of visual function(More)
Anisometropic and strabismic amblyopes were studied using the Regan Contrast Sensitivity Charts. At all levels of contrast, the amblyopic eyes of both the strabismic and anisometropic patients scored significantly lower than did their fellow normal eyes, which were used as controls. In comparing the differences between the normal and amblyopic eyes of both(More)
The clinical spectrum of electrical injuries is complex and diverse. Despite the high annual incidence of electrical accidents, little has been reported recently regarding the neurological deficits associated with this form of trauma. The most frequently cited reviews are those of Critchley, Langworthy, Naville and De Morsier, and Silversides. These authors(More)