Mark Fitzgerald

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BACKGROUND Treatment of moderate or severe chronic obstructive pulmonary disease (COPD) with combinations of inhaled corticosteroids, long-acting beta-agonists, and long-acting anticholinergic bronchodilators is common but unstudied. OBJECTIVE To determine whether combining tiotropium with salmeterol or fluticasone-salmeterol improves clinical outcomes in(More)
Although numerous paediatric-based health-related quality-of-life (HR-QOL) instruments are currently in use, there still remain conceptual, methodological and developmental issues to address. This paper provides an up-to-date critical review of the HR-QOL literature in paediatric medicine. Our analysis indicates that there is no consensus on how HR-QOL and(More)
BACKGROUND In 2010, the Canadian Thoracic Society (CTS) published a Consensus Summary for the diagnosis and management of asthma in children six years of age and older, and adults, including an updated Asthma Management Continuum. The CTS Asthma Clinical Assembly subsequently began a formal clinical practice guideline update process, focusing, in this first(More)
This paper presents some alternate theories for explaining the term 'initiative', as it is used in the design of mixed-initiative AI systems. Although there is now active research in the area of mixed initiative interactive systems, there appears to be no true consensus in the field as to what the term 'initiative' actually means. In describing different(More)
RATIONALE Small studies have suggested that inhaled corticosteroids can suppress systemic inflammation in chronic obstructive pulmonary disease (COPD). OBJECTIVES To determine the effect of inhaled corticosteroids with or without long-acting beta(2)-adrenergic agonist on systemic biomarkers of inflammation. METHODS We conducted a double-blind randomized(More)
The radiological features of seven cases of pelvic digit discovered incidentally on plain radiographs are described and differentiation from other causes of new bone formation is discussed. Its recognition as a benign anomaly is important to avoid unnecessary investigation or intervention. An embryological theory of development of pelvic digit is proposed.
BACKGROUND Asthma is difficult to diagnose in children and at times misdiagnosis of an infection can occur. However, little is known about the magnitude and patterns of antibiotic consumption in children with asthma relative to those without asthma. METHODS Using population-based data, 128,872 children were identified with at least 6 years of follow-up.(More)
BACKGROUND Many molecular epidemiology studies have been conducted to identify risk factors for clustering of tuberculosis (TB) cases in the population. OBJECTIVE To estimate the impact of commonly investigated risk factors on TB clustering. METHODS Ten electronic databases were searched up to January 2006 along with a hand search of the International(More)
BACKGROUND Long-acting ss(2)-agonists are an established controller medication in asthma. BI 1744 is a novel L\long-acting ss(2)-agonist with a preclinical profile that suggests 24-hour bronchodilation and bronchoprotection may be achieved. OBJECTIVE To examine the bronchoprotective effects of single doses of BI 1744 against methacholine provocation in(More)
BACKGROUND There are no published studies that have assessed whether adding long-acting beta 2-agonist bronchodilators and/or inhaled steroids to chronic therapy with tiotropium would provide additional clinical benefit to patients with moderate to severe chronic obstructive pulmonary disease (COPD). METHODS The Canadian Optimal Therapy of COPD Trial is a(More)