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Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation
The Mre11/Rad50/NBS1 (MRN) complex maintains genomic stability by bridging DNA ends and initiating DNA damage signaling through activation of the ATM kinase. Mre11 possesses DNA nuclease activitiesExpand
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Histone H2AX A Dosage-Dependent Suppressor of Oncogenic Translocations and Tumors
We employed gene targeting to study H2AX, a histone variant phosphorylated in chromatin surrounding DNA double-strand breaks. Mice deficient for both H2AX and p53 (H(delta/delta)P(-/-)) rapidlyExpand
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Defective DNA Repair and Increased Genomic Instability in Artemis-deficient Murine Cells
In developing lymphocytes, the recombination activating gene endonuclease cleaves DNA between V, D, or J coding and recombination signal (RS) sequences to form hairpin coding and blunt RS ends, whichExpand
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The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability
Sirtuin deacetylases promote longevity in invertebrates. Mammals possess seven sirtuin homologs, which are involved in a diverse array of processes including development, metabolism, and stressExpand
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Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells.
The nonhomologous DNA end-joining (NHEJ) pathway contains six known components, including Artemis, a nuclease mutated in a subset of human severe combined immunodeficient patients. Mice doublyExpand
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Calorie restriction alters mitochondrial protein acetylation
Calorie restriction (CR) increases lifespan in organisms ranging from budding yeast through mammals. Mitochondrial adaptation represents a key component of the response to CR. Molecular mechanismsExpand
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Functional Interaction of H2AX, NBS1, and p53 in ATM-Dependent DNA Damage Responses and Tumor Suppression
ABSTRACT Ataxia-telangiectasia (A-T) mutated (ATM) kinase signals all three cell cycle checkpoints after DNA double-stranded break (DSB) damage. H2AX, NBS1, and p53 are substrates of ATM kinase andExpand
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Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability.
Nonhomologous end joining (NHEJ) and homologous recombination (HR) represent the two major pathways of DNA double-strand break (DSB) repair in eukaryotic cells. NHEJ repairs DSBs by ligation ofExpand
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Rad50 depletion impacts upon ATR-dependent DNA damage responses.
The Mre11/Rad50/NBS1 (MRN) complex is mutated in inherited genomic instability syndromes featuring cancer predisposition, mental retardation and immunodeficiency. It functions both in DNAExpand
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C. elegans SIRT6/7 Homolog SIR-2.4 Promotes DAF-16 Relocalization and Function during Stress
FoxO transcription factors and sirtuin family deacetylases regulate diverse biological processes, including stress responses and longevity. Here we show that the Caenorhabditis elegans sirtuinExpand
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