Mark E Wise

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When a clearance curve in pharmacokinetic studies--and in tracer kinetics in general--is well fitted by a sum of negative exponentials of time, in very many cases the data would also be well fitted over much or all of the same period by a function of time consisting mainly of a negative power or by a gamma function. There are also instances where two such(More)
This experiment was undertaken to determine whether the estrogen-induced LH and GnRH surge in the ewe is associated with activation of a specific subpopulation of neurons in the mid-brain of the ewe as indicated by a change in GnRH mRNA levels. Fifteen ovariectomized ewes were assigned to treatment groups 3-4 wk after ovariectomy. One group of ewes served(More)
While water insoluble organics are prevalent in the atmosphere, it is not clear how the presence of such species alters the chemical and physical properties of atmospheric aerosols. Here we use a combination of FTIR spectroscopy, Transmission Electron Microscopy (TEM) and Aerosol Mass Spectrometry (AMS) to characterize ammonium sulfate particles coated with(More)
Gonadotropin-releasing hormone (GnRH) receptor expression is regulated by estradiol and GnRH itself. The objective of this experiment was to determine the extent to which low levels of estradiol, similar to those observed during the transition from the luteal to the follicular phase of the estrous cycle, and GnRH interact to regulate expression of GnRH(More)
The object of this investigation was to determine whether chronic lateral ventricle infusion of a pineal gland-derived antigonadotropic decapeptide (AGD) would affect pulsatile luteinizing hormone (LH) release in conscious, unrestrained male rats. Adult male Harlan SD rats were bilaterally orchiectomized and maintained under conditions of controlled(More)
Amiodarone concentrations y(t) have been measured from 1 min to more than 50 days following 10 min of infusion, with about 40 observations on each of six normal subjects (Tucker et al., 1984, Eur. J. clin. Pharmacol. 26, 655-656). The form of the log-log plots-ln(y) vs ln(t)--is investigated. These appear to show three phases. First there is a rapid(More)
The behavioral responses of cattle under the influence of naturally occurring seasonal horn fly, Haematobia irritans (L.), populations were evaluated under rangeland conditions. This study was replicated four times using 10 cows as the subsampling unit equipped with GPS collars scheduled to receive locational fixes every 5 min for 6 d prior to, and 6 d(More)
While water insoluble organics are prevalent in the atmosphere, it is not clear how the presence of such species alters the chemical and physical properties of atmospheric aerosols. Here we use a combination of FTIR spectroscopy, Transmission Electron Microscopy (TEM) and Aerosol Mass Spectrometry (AMS) to characterize ammonium 5 sulfate particles coated(More)
Expression of GnRH receptors increases prior to the onset of the preovulatory surge of LH in sheep. Two experiments were conducted to investigate the interactions of progesterone (P) and estradiol (E) on amounts of mRNA for GnRH receptors and the number of receptors for GnRH. The first study was designed as a 2 x 2 factorial arrangement of treatments to(More)
The sensitivity of the hypothalamic-pituitary axis to estradiol was evaluated by monitoring changes in the concentration of receptors for estradiol during gestation and the postpartum period of the ewe. Ewes that had been bred during anestrus so that lambing would occur during the breeding season were killed on d 50 and 140 of gestation or on d 2, 13, 22(More)