Mark E. Marsden

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BACKGROUND The pathophysiology of aortic stenosis is incompletely understood, and the relative contributions of valvular calcification and inflammation to disease progression are unknown. METHODS AND RESULTS Patients with aortic sclerosis and mild, moderate, and severe stenosis were compared prospectively with age- and sex-matched control subjects. Aortic(More)
2.87 0.82 versus 1.55 0.17; 18F-FDG: 1.58 0.21 versus 1.30 0.13; both P 0.001). 18F-NaF uptake displayed a progressive rise with valve severity (r 0.540, P 0.001), with a more modest increase observed for 18F-FDG (r 0.218, P 0.001). Among patients with aortic stenosis, 91% had increased 18F-NaF uptake ( 1.97), and 35% had increased 18F-FDG uptake ( 1.63). A(More)
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