Current medical imaging technologies allow visualization of tissue anatomy in the human body at resolutions ranging from 100 micrometers to 1 millimeter. These technologies are generally not sensitive enough to detect early-stage tissue abnormalities associated with diseases such as cancer and atherosclerosis, which require micrometer-scale resolution.… (More)
A Kerr-lens mode-locked Ti:Al(2)O(3) oscillator, optimized for minimal coherence length, is demonstrated as a high-power source for high-resolution optical coherence tomographic imaging. Dispersion compensation and heterodyne noise rejection are demonstrated to yield in situ images of biological tissues with 3.7-mum resolution and 93-dB dynamic range.
Studies investigating normal and abnormal cardiac development are frequently limited by an inability to assess cardiovascular function within the intact organism. In this work, optical coherence tomography (OCT), a new method of micron-scale, noninvasive imaging based on the measurement of backscattered infrared light, was introduced for the high resolution… (More)
Optical Coherence Tomography (OCT) is a recently developed non-invasive technique for obtaining high resolution, cross-sectional images of human tissue. This work investigated the capability of OCT to differentiate the architectural morphology of urologic tissue with the long term aim of using OCT as an adjunct to endoscopic imaging and to improve the… (More)
OBJECTIVE Intraoperative identification of brain tumors and tumor margins has been limited by either the resolution of the in vivo imaging technique or the time required to obtain histological specimens. Our objective was to evaluate the feasibility of using optical coherence tomography (OCT) as a high-resolution, real-time intraoperative imaging technique… (More)
We discuss the design and implementation of forward-imaging instruments for optical coherence tomography (OCT), which require the delivery, scanning, and collection of single-spatial-mode optical radiation. A hand-held surgical probe for use in open surgery can provide cross-sectional images of subsurface tissue before surgical incisions are made. A rigid… (More)
We describe a new optical coherence tomography catheter-endoscope for micrometer-scale, cross-sectional imaging in internal organ systems. The catheter-endoscope uses single-mode fiber optics with a novel transverse scanning design. The distal end of the catheter-endoscope uses a gradient-index lens with a microprism to emit and collect a single… (More)
BACKGROUND Optical coherence tomography (OCT) is a recently developed compact technology which uses infrared light to perform cross-sectional imaging on a micrometer scale. Since OCT provides imaging at a resolution comparable to conventional histology and does not require direct contact with the tissue surface, a role in real-time surgical diagnostics… (More)
BACKGROUND Optical coherence tomography (OCT) is a new method of catheter based micron scale imaging. OCT is analogous to ultrasound, measuring the intensity of backreflected infrared light rather than sound waves. OBJECTIVE To demonstrate the ability of OCT to perform high resolution imaging of arterial tissue in vivo. METHODS OCT imaging of the… (More)
OCT achieves high-resolution and image differentiation of vascular tissues to a degree that has not been previously possible with any method except excisional biopsy. Thus, OCT represents a promising new diagnostic technology for intracoronary imaging, which could permit the in vivo evaluation of critical vascular pathology.