Mark E. Astill

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Many methodologies have been used in research to identify the “intrinsic” subtypes of breast cancer commonly known as Luminal A, Luminal B, HER2-Enriched (HER2-E) and Basal-like. The PAM50 gene set is often used for gene expression-based subtyping; however, surrogate subtyping using panels of immunohistochemical (IHC) markers are still widely used(More)
OBJECTIVES To determine the clinical utility and performance characteristics of a laboratory-adapted flow cytometric method for the detection of acetylcholine receptor (AChR) modulating antibodies in myasthenia gravis (MG). METHODS Serum samples from 120 healthy donors and 100 patients with suspected MG were assessed for the ability to reduce surface AChR(More)
Objectives: Paraneoplastic myasthenia gravis (MG) often has a serologic profile with high titer anti-striated muscle antibodies in addition to the acetylcholine receptor autoantibodies associated with MG. Immunologic classification serves as an adjunct to the clinical classification system published by the Medical Scientific Advisory Board of the Myasthenia(More)
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