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Increased mitochondrial NADPH oxidase 4 (NOX4) expression in aging is a causative factor in aortic stiffening
- Chandrika Canugovi, Mark D Stevenson, +7 authors N. Madamanchi
- Chemistry, Medicine
- Redox biology
- 2 August 2019
Aging is characterized by increased aortic stiffness, an early, independent predictor and cause of cardiovascular disease. Oxidative stress from excess reactive oxygen species (ROS) production… Expand
Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice
- Aleksandr E. Vendrov, Mark D Stevenson, +4 authors M. Runge
- Journal of the American Heart Association
- 27 October 2017
Background Atherosclerosis progression during aging culminates in the development of vulnerable plaques, which may increase the risk of cardiovascular events. Increased generation and/or decreased… Expand
NADPH Oxidase 4 Regulates Inflammation in Ischemic Heart Failure: Role of Soluble Epoxide Hydrolase.
- Mark D Stevenson, Chandrika Canugovi, +5 authors M. Runge
- Antioxidants & redox signaling
- 21 May 2019
Aims: Oxidative stress is implicated in cardiomyocyte cell death and cardiac remodeling in the failing heart. The role of NADPH oxidase 4 (NOX4) in cardiac adaptation to pressure overload is… Expand
Abstract 16724: NADPH Oxidase 4 Contributes to Ischemic Cardiomyopathy by Activating Soluble Epoxide Hydrolase
- Mark D Stevenson, Chandrika Canugovi, Aleksandr E. Vendrov, D. Bowles, N. Madamanchi, M. Runge
- 14 November 2017
Congestive heart failure afflicts an estimated 5 million Americans, contributing to ~287,000 deaths a year. Oxidative stress generated by NOX family NADPH oxidases is implicated in adverse cardiac ...
Abstract 212: Low Intrinsic Aerobic Capacity Promotes Vascular Dysfunction In Aging
The association between low aerobic capacity and increased cardiovascular events, morbidity and mortality in aging is well established; however, the underlying mechanisms of vascular dysfunction ar...
Abstract 19685: Noxa1-Dependent Regulation of Nox1 NADPH Oxidase Activity in the Development of Angiotensin II-Induced Hypertension and an Early Phase of Renal Na+ Retention
Abnormal renal function, a major contributor to hypertension (HTN), in conjunction with oxidative stress, enhances the risk for renal failure and the development of cardiovascular disease. Increased… Expand
Abstract 17153: Increased Atherosclerotic Plaque Instability in Advanced Atherosclerosis with Aging: the Role of Calpain 2 in SOD2-deficient ApoE-/- Mice
The prevalence of atherosclerosis and incidence of cardiovascular events increase with advancing age. Increased generation and/or decreased scavenging of reactive oxygen species (ROS) in the vascular… Expand