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BACKGROUND Findings from a recent large study suggest that perchlorate at commonly occurring exposure concentrations may decrease thyroid hormone levels in some women. Decreases in thyroid hormone seen with perchlorate exposure could be even greater in people with concomitant exposure to agents such as thiocyanate that may affect the thyroid by mechanisms(More)
OBJECTIVE This study examined the effects of maintenance treatment for late-life depression on social adjustment. The authors hypothesized that elderly patients recovering from depression would have better social adjustment with medication and interpersonal psychotherapy than with medication or psychotherapy alone. METHOD Patients aged 60 and older(More)
BACKGROUND Comorbid anxiety is common in depressive disorders in both middle and late life, and it affects response to antidepressant treatment. AIMS To examine whether anxiety symptoms predict acute and maintenance (2 years) treatment response in late-life depression. METHOD Data were drawn from a randomised double-blind study of pharmacotherapy and(More)
OBJECTIVE To describe the clinical effect and safety of low-dose buprenorphine, a κ-opioid receptor antagonist, for treatment-resistant depression (TRD) in midlife and older adults. METHOD In an 8-week open-label study, buprenorphine was prescribed for 15 adults aged 50 years or older with TRD, diagnosed with the Structured Clinical Interview for DSM-IV,(More)
OBJECTIVE To evaluate associations between maternal drinking water perchlorate exposure during pregnancy and newborn thyroid hormone levels. METHODS Elevation in thyroid stimulating hormone (TSH), which may reflect reduced thyroxin concentration, was assessed in 497,458 newborns in California in 1998. A total of 800 perchlorate water measurements were(More)
OBJECTIVE/METHODS The authors examined recurrence rates of major depression in elderly subjects with different foci of interpersonal psychotherapy (IPT), who were treated for up to 3 years with either monthly maintenance IPT and pill placebo or with monthly clinical management and pill placebo. RESULTS Among subjects with an IPT focus on role conflict, a(More)
OBJECTIVE The vascular depression hypothesis posits that depression can arise in late life from cerebrovascular damage and that depression arising this way has a different clinical presentation and is more chronic and treatment-resistant than early-onset depression. This study tested the relationship of cerebrovascular risk factors (CVRF) to clinical(More)
Considerable controversy and uncertainty have surrounded the biological function of the Human Immunodeficiency Virus (HIV)-1 nef gene product. Initial studies suggested that this early, nonstructural viral protein functioned as a negative regulatory factor; thus, it was proposed to play a role in establishing or maintaining viral latency. In contrast,(More)
We report an empirical study of people using mobile collaborative systems to support maintenance tasks on a bicycle. Results show that field workers make repairs more quickly and accurately when they have a remote expert helping them. Some pairs were connected by a shared video system, where the video camera focused on the active workspace and they(More)