Mark Carrington

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Interleukin-1 polymorphisms associated with increased risk of gastric cancer.

E.M. El-Omar, Mark Carrington, +11 authors Charles S. Rabkin
Nature
2000

Helicobacter pylori infection is associated with a variety of clinical outcomes including gastric cancer and duodenal ulcer disease. The reasons for this variation are not clear, but the gastric… (More)

Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter…

M. Dean, Mark Carrington, +14 authors S. J. O'Brien
Science
1996

The chemokine receptor 5 (CKR5) protein serves as a secondary receptor on CD4(+) T lymphocytes for certain strains of human immunodeficiency virus-type 1 (HIV-1). The CKR5 structural gene was mapped… (More)

The genome of the African trypanosome Trypanosoma brucei.

Matthew Berriman, Elodie Ghedin, +99 authors Najib M El-Sayed
Science
2005

African trypanosomes cause human sleeping sickness and livestock trypanosomiasis in sub-Saharan Africa. We present the sequence and analysis of the 11 megabase-sized chromosomes of Trypanosoma… (More)

The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease.

Najib M El-Sayed, Peter J. Myler, +79 authors Björn Andersson
Science
2005

Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs.… (More)

HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.

Mark Carrington, Geoffrey W Nelson, +7 authors S. J. O'Brien
Science
1999

A selective advantage against infectious disease associated with increased heterozygosity at the human major histocompatibility complex [human leukocyte antigen (HLA) class I and class II] is… (More)

TriTrypDB: a functional genomic resource for the Trypanosomatidae

Martin Aslett, Cristina Aurrecoechea, +41 authors Haiming Wang
Nucleic Acids Research
2010

TriTrypDB (http://tritrypdb.org) is an integrated database providing access to genome-scale datasets for kinetoplastid parasites, and supporting a variety of complex queries driven by research and… (More)

Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia…

C. Winkler, William S. Modi, +19 authors S. J. O'Brien
Science
1998

Stromal-derived factor (SDF-1) is the principal ligand for CXCR4, a coreceptor with CD4 for T lymphocyte cell line-tropic human immunodeficiency virus-type 1 (HIV-1). A common polymorphism, SDF1-3'A,… (More)

Influence of combinations of human major histocompatibility complex genes on the course of HIV–1 infection

Richard A. Kaslow, Mark Carrington, +12 authors D. L. Mann
Nature Medicine
1996

Major histocompatibility complex (MHC) genes (HLA in humans) regulate the immune response to foreign antigens. Molecular and serologic techniques were used to identify products of HLA class I, class… (More)

Autonomic activity during human sleep as a function of time and sleep stage.

John A Trinder, Jay H Kleiman, +4 authors Y Kim
Journal of sleep research
2001

While there is a developing understanding of the influence of sleep on cardiovascular autonomic activity in humans, there remain unresolved issues. In particular, the effect of time within the sleep… (More)

Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter…

Melody Smith, M. Dean, +13 authors S. J. O'Brien
Science
1997

The critical role of chemokine receptors (CCR5 and CXCR4) in human immunodeficiency virus-type 1 (HIV-1) infection and pathogenesis prompted a search for polymorphisms in other chemokine receptor… (More)

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