Mark C. Williams

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We used single DNA molecule stretching to investigate DNA intercalation by ethidium and three ruthenium complexes. By measuring ligand-induced DNA elongation at different ligand concentrations, we determined the binding constant and site size as a function of force. Both quantities depend strongly on force and, in the limit of zero force, converge to the(More)
A procedure for modeling and simulation of arbitrary nonlinear magnetics components is presented. A set of electromagnetic primitives is described as implemented in Ver-ilog-A. The primitives include cores, gaps, and windings that are combined to model ferromagnetic inductors and transformers. The physics of the ferromagnetic core model is described. The(More)
The diverse properties of DNA intercalators, varying in affinity and kinetics over several orders of magnitude, provide a wide range of applications for DNA-ligand assemblies. Unconventional intercalation mechanisms may exhibit high affinity and slow kinetics, properties desired for potential therapeutics. We used single-molecule force spectroscopy to probe(More)
A procedure for modeling and simulation of arbitrary nonlinear magnetics components is presented. A set of electromagnetic primitives is described as implemented in Ver-ilog-A. The primitives include cores, gaps, and windings that are combined to model ferromagnetic inductors and transformers. The physics of the ferromagnetic core model is described. The(More)
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