Mark C Regan

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Patients who present during pregnancy with acute abdominal symptoms often present a significant diagnostic challenge. Although ultrasound is often the first mode of abdominal imaging, in complex cases further imaging is often necessary. MRI of the small bowel has been made possible with the development of rapid scanning techniques. This has increased the(More)
BACKGROUND Patients who are undergoing laparoscopic procedures can present with a number of ventilatory and circulatory problems. The use of a gasless technique for performing a laparoscopy by using a mechanical lifting device may potentially avoid such problems. OBJECTIVE To compare the cardiorespiratory effects of laparoscopy with and without gas(More)
Recently there has been much interest in the use of arginine to stimulate immune responses and to promote wound healing. In the present study, the effect of an oral supplementation with arginine on the metabolism of 45 healthy, nonsmoking, elderly volunteers was investigated. Subjects were divided into two groups that received either arginine aspartate (17(More)
Fibroblasts are fundamental to successful wound healing. We hypothesized that the induction and regulation of various fibroblast functions (proliferation, collagen synthesis, and remodeling) are determined by the wound environment. We examined the effect of wound fluid (WF), as a reflection of the wound environment, on the phenotypic expression of normal(More)
Renal function is intimately dependent on renal blood flow. Alterations in either total or regional renal blood flow have major consequences for renal function. Through homeostatic mechanisms the kidneys are able to maintain relatively stable rates of flow over a wide range of perfusion pressures. A combination of neural, endocrine, exocrine and autocrine(More)
Both in vitro and in vivo studies have demonstrated that the presence of both macrophages and T lymphocytes at the wound site is essential in order for the normal healing process to occur. Both macrophages and T lymphocytes possess the capacity to regulate essential steps in the process of wound healing. The presence of macrophages is essential for the(More)
OBJECTIVE To determine whether intestinal fibroblasts in patients with Crohn's disease (CD) have an enhanced capacity to reorganize collagen and thus cause stricture formation. SUMMARY BACKGROUND DATA Stricture formation is a characteristic feature of CD that may distinguish it from other forms of inflammatory bowel disease. Methods Fibroblasts were(More)
BACKGROUND The effects of operative trauma on systemic immunity were studied. The relative effects of skin incision and of breaching the peritoneum were determined. In addition, the role of the antiendotoxic agent taurolidine in preventing postoperative immune suppression was assessed. METHODS Systemic immune responsiveness was measured as the(More)
BACKGROUND Although the elderly clinically have a higher rate of wound complications, the physiologic effect of age on wound healing in human beings is unknown. METHODS Healthy young (18 to 55 years of age) and elderly (more than 65 years of age) human volunteers had a 2 x 2 cm, superficial, split-thickness wound created on the anterior aspect of the(More)