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We describe kinetic control of DNA hybridization: loop complexes are used to inhibit the hybridization of complementary oligonucleotides; rationally designed DNA catalysts are shown to be effective in promoting their hybridization. This is the basis of a strategy for using DNA as a fuel to drive free-running artificial molecular machines.
This paper proposes a new class of replicated distributed databases offering high levels of dism*bution transparency for very large networks of processing sites. The class is distinguished by the restriction that processing sites possess limited rather than complete knowledge of the data objects and sites in the system. The traditional data directory is… (More)
<italic>The problems inherent in managing a database distributed over a very large number of sites are considered. The applications of such databases to the provision of telecommunications and other public services are discussed. It is shown that the distribution and maintenance of the directory information describing object locations poses some fundamental… (More)