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To develop a genetically faithful model of medulloblastoma with increased tumor incidence compared with the current best model we activated the Sonic Hedgehog (Shh) pathway by transgenically expressing a constitutively active form of Smoothened in mouse cerebellar granule neuron precursors (ND2:SmoA1 mice). This resulted in early cerebellar granule cell(More)
ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/) at the National Center for Biotechnology Information (NCBI) is a freely available archive for interpretations of clinical significance of variants for reported conditions. The database includes germline and somatic variants of any size, type or genomic location. Interpretations are submitted by clinical(More)
BACKGROUND/AIMS Currently the diagnosis and severity of hepatic steatosis can be established accurately only by liver biopsy. Previous small studies found that steatosis measured by magnetic resonance spectroscopy (MRS) and imaging (MRI) correlated with histological assessment of liver triglyceride content. However, the accuracy of MRS/MRI for grading the(More)
BACKGROUND AND STUDY AIMS Endoscopic balloon dilation of Crohn's strictures is widely practised, but may not result in long-term symptomatic benefit, leading to the need for repeat dilation or surgery. It is hypothesized that long-acting steroid injection into strictures after dilation may decrease the need for further stricture dilation and improve the(More)
Under standardized conditions, the manometric motility of the distal colon following rectosigmoid anastomosis (N=11, median age 70 years, range 47–80), was compared to that following laparotomies not involving colonic anastomosis (N=9, 56 years, 32–65). Microtransducer probes were inserted peroperatively and colonic activity recorded continuously (median 96(More)
Complementary and alternative medicine (CAM) use has increased in popularity in recent years and herbal therapy alone is now a billion dollar market. For centuries herbs have been used as food and for medicinal purposes. Various herbs have been identified as possessing anti-inflammatory and antioxidative properties, and they are currently being used to(More)
To develop a genetically faithful model of medulloblastoma with increased tumor incidence compared with the current best model we activated the Sonic Hedgehog (Shh) pathway by transgenically expressing a constitutively active form of Smoothened in mouse cerebellar granule neuron precursors (ND2:SmoA1 mice). This resulted in early cerebellar granule cell(More)
This article evaluates the costs and outcomes associated with TEE during and after cardiac surgery. The costs include the direct and indirect costs--the complications of TEE. The outcomes include the positive consequences or the benefits: money and lives saved. The article uses liberal (high) estimates of the direct and indirect costs of TEE and(More)
The editorial team of Digestive Diseases and Sciences (DDS) wishes to acknowledge and thank the individuals whose names appear in the following list of reviewers year 2012. Manuscript reviews by these research scientists, clinical investigators, and members of the editorial board, are fundamental to the excellence and integrity of the journal and are vital(More)
The editorial team of Digestive Diseases and Sciences (DDS) wishes to acknowledge the critically important role played by the individuals whose names appear in the following list of reviewers for calendar year 2009. Manuscript reviews by these clinical and research scientists, as well as by members of the editorial board, are the cornerstone of the journal(More)