Mark Becker

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The efflux pump P-glycoprotein decreases drug penetration into cells and tissues. To determine whether nelfinavir or its metabolites inhibit P-glycoprotein in lymphocytes from a healthy volunteer, whole blood cells from human immunodeficiency virus-negative donors were incubated either in human plasma to which nelfinavir or its M8 metabolite were added ex(More)
BACKGROUND The nucleotide analogue, tenofovir, has been shown to lower plasma atazanavir levels in pharmacokinetic trials, an interaction that may be partly reversed by the addition of ritonavir, whereas plasma tenofovir levels are themselves raised when the drug is combined with lopinavir/ritonavir. OBJECTIVE To investigate the effect of tenofovir(More)
Emergency care research (ECR) does not fit neatly into the traditional National Institutes of Health (NIH) funding model, because emergency research involves undifferentiated disease presentations involving multiple disciplines and time-sensitive interventions. A task force of emergency care researchers and other stakeholders was convened to discuss the(More)
Program monitoring and evaluation (M&E) has the potential to be a cornerstone of health systems strengthening and of evidence-informed implementation and scale-up of HIV-related services in resource-limited settings. We discuss common challenges to M&E systems used in the rapid scale-up of HIV services as well as innovations that may have relevance to(More)
In a classic statement, Hauser and Duncan (1959) defined demography as " the study of the size, territorial distribution , and composition of population, changes therein, and the components of such changes " (p. 2). It was fortunate that Hauser and Duncan explicitly included " composition of population " and " changes therein " in their definition, for(More)
We have designed a research platform for a perceptually guided robot, which also serves as a demonstrator for a coming generation of service robots. In order to operate semi-autonomously, these require a capacity for learning about their environment and tasks, and will have to interact directly with their human operators. Thus, they must be supplied with(More)
The dominant s c i e n tiic methodology for short term forecasting in important elections uses trial-heat polls, in which a sample of respondents report their current electoral preferences. Election markets, where self-selected participants trade shares of candidates at prices predictive of election day results, provide an alternative forecasting method.(More)
OBJECTIVES This study evaluated the steady-state pharmacokinetic interaction between ritonavir-boosted saquinavir and nelfinavir. METHODS Open label, multiple-dose, two parallel-groups, single crossover study conducted in 24 HIV-infected patients (12 in each group). Patients in the nelfinavir group added saquinavir/ritonavir, 1000/100 mg twice daily to(More)
The objective of the NASA Global Climate Change Education (GCCE) project is to provide educators at the elementary, secondary, and undergraduate levels the tools and resources to access NASA climate information and related Earth system information, in order to engage students in critical thinking about global climate change and the potential impacts on(More)
This talk introduces GripSee, our robot platform for gesture and object recognition, object manipulation and learning. As modeling visual perception invariably means modeling human visual perception we have chosen to let the robot components, speciically the arrangement and kinematics of camera head and robot manipulator, closely resemble the human eye,(More)