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UNLABELLED (11)C-ABP688 is a new PET ligand to assess the subtype 5 metabotropic glutamate receptor (mGlu(5)). The purpose of this study was to evaluate different methods for the analysis of human (11)C-ABP688 data acquired from 6 healthy, young volunteers. METHODS The methods were a 1-tissue-compartment model (K(1), k(2)''), a 2-tissue-compartment model(More)
In this study we assessed the new glutamatergic ligand (11)C-ABP688 with regard to the following characteristics: (A) brain distribution, (B) first pass extraction fraction, (C) suitable model to describe tracer kinetics and (D) specificity for the mGlu5 receptor. These parameters were assessed using autoradiography and a beta-scintillator positioned in the(More)
UNLABELLED 3-(6-Methyl-pyridin-2-ylethynyl)-cyclohex-2-enone-O-11C-methyl-oxime (11C-ABP688), a noncompetitive and highly selective antagonist for the metabotropic glutamate receptor subtype 5 (mGluR5), was evaluated for its potential as a PET agent. METHODS Six healthy male volunteers (mean age, 25 y; range, 21-33 y) were studied. Brain perfusion(More)
With the increased dependence on networks and the near ubiquitous availability of the Internet, there is a new paradigm in place for the proliferation of spyware, viruses, and other malware. In fact, much attention has been given to spyware in popular literature with reports from multiple sources indicating that spyware has perhaps reached 90% home user PCs(More)
Despite numerous advances in IT security, many computer users are still vulnerable to security-related risks because they do not comply with organizational policies and procedures. In a network setting, individual risk can extend to all networked users. Endpoint security refers to the set of organizational policies, procedures, and practices directed at(More)
Despite the recent increased attention afforded malware by the popular press, there appears to be a dearth in user awareness and understanding of certain aspects of the security paradigm. This article presents a comparison of user awareness levels of rootkits, spyware, and viruses between U.S. and Chinese users. The results of a survey of 210 U.S.(More)