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UNLABELLED 3-(6-Methyl-pyridin-2-ylethynyl)-cyclohex-2-enone-O-11C-methyl-oxime (11C-ABP688), a noncompetitive and highly selective antagonist for the metabotropic glutamate receptor subtype 5 (mGluR5), was evaluated for its potential as a PET agent. METHODS Six healthy male volunteers (mean age, 25 y; range, 21-33 y) were studied. Brain perfusion(More)
This article describes an attempt to infect two new Dell WindowsXP-SP2 PCs (named Grease and Grime) with spyware and examines the results of the spyware infections. Each PC carried Symantec Antivirus, Spyware Doctor 3.1 (Doc), Spybot Search and Destroy 1.3 (SSD), and Sandra 2005 software, but no inoculation options were active during the infection(More)
This project surveys and examines optimization approaches proposed for parameter estimation in Least Squares linear regression models with an L1 penalty on the regression coefficients. We first review linear regression and regularization, and both motivate and formalize this problem. We then give a detailed analysis of 8 of the varied approaches that have(More)
UNLABELLED (11)C-ABP688 is a new PET ligand to assess the subtype 5 metabotropic glutamate receptor (mGlu(5)). The purpose of this study was to evaluate different methods for the analysis of human (11)C-ABP688 data acquired from 6 healthy, young volunteers. METHODS The methods were a 1-tissue-compartment model (K(1), k(2)''), a 2-tissue-compartment model(More)
In this study we assessed the new glutamatergic ligand (11)C-ABP688 with regard to the following characteristics: (A) brain distribution, (B) first pass extraction fraction, (C) suitable model to describe tracer kinetics and (D) specificity for the mGlu5 receptor. These parameters were assessed using autoradiography and a beta-scintillator positioned in the(More)
BACKGROUND In January 2005, a quadrivalent (serogroups A, C , Y, and W-135) meningococcal conjugate vaccine was licensed for use in adolescents. This report describes the epidemiologic features of meningococcal disease in the United States from January 1998 through December 2007, before and during implementation of adolescent quadrivalent meningococcal(More)
With the increased dependence on networks and the near ubiquitous availability of the Internet, there is a new paradigm in place for the proliferation of spyware, viruses, and other malware. In fact, much attention has been given to spyware in popular literature with reports from multiple sources indicating that spyware has perhaps reached 90% home user PCs(More)