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Sickle cell trait (SCT) is a condition in which an individual inherits one sickle hemoglobin gene (HbS) and one normal beta hemoglobin gene (HbA). It has been hypothesized that under extreme physical stress, the compromised mechanical properties of the red blood cells (RBCs) may be the underlying mechanism of clinical complications of sickle cell trait(More)
This paper reports the first study of stiffness/deformability changes of lymphocytes in chronic lymphocytic leukemia (CLL) patients, demonstrating that at the single cell level, leukemic metastasis progresses are accompanied by biophysical property alterations. A microfluidic device was utilized to electrically measure cell volume and transit time of single(More)
Proponents of Agile development processes claim that adhering to Agile principles leads to the delivery of high quality code in evolutionary increments. Confidence in resulting systems is mostly gained through the use of unit test suites, entrusted to catch regressions as soon as they occur. Consequently, the system can only be as trustworthy as its tests,(More)
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