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  • Mark Akeson, Daniel Branton, John J Kasianowicz, Eric Brandin, David Deamer
  • Biology, Medicine
  • Biophysical journal
  • 1999 (First Publication: 1 December 1999)
  • Single molecules of DNA or RNA can be detected as they are driven through an alpha-hemolysin channel by an applied electric field. During translocation, nucleotides within the polynucleotide mustContinue Reading
  • Wenonah Vercoutere, Stephen Winters-Hilt, Hugh E. Olsen, David Deamer, David Haussler, Mark Akeson
  • Medicine, Biology
  • Nature Biotechnology
  • 2001 (First Publication: 1 March 2001)
  • RNA and DNA strands produce ionic current signatures when driven through an α-hemolysin channel by an applied voltage. Here we combine this nanopore detector with a support vector machine (SVM) toContinue Reading
  • Gerald M. Cherf, Kate R. Lieberman, Hytham Rashid, Christopher E. Lam, Kevin Karplus, Mark Akeson
  • Medicine, Biology
  • Nature Biotechnology
  • 2012 (First Publication: 14 February 2012)
  • An emerging DNA sequencing technique uses protein or solid-state pores to analyze individual strands as they are driven in single-file order past a nanoscale sensor. However, uncontrolledContinue Reading
  • Stephen Winters-Hilt, Wenonah Vercoutere, Veronica Deguzman, David Deamer, Mark Akeson, David Haussler
  • Biology, Medicine
  • Biophysical journal
  • 2003 (First Publication: 1 February 2003)
  • We introduce a computational method for classification of individual DNA molecules measured by an alpha-hemolysin channel detector. We show classification with better than 99% accuracy for DNAContinue Reading
  • Ashley Byrne, Anna E Beaudin, +7 authors Christopher Vollmers
  • Biology, Medicine
  • Nature communications
  • 2017 (First Publication: 19 July 2017)
  • Understanding gene regulation and function requires a genome-wide method capable of capturing both gene expression levels and isoform diversity at the single-cell level. Short-read RNAseq is limitedContinue Reading