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- Aidan G. Gilmartin, Thomas H. Faitg, +24 authors Rakesh Kumar
- Nature chemical biology
- 2014
Although therapeutic interventions of signal-transduction cascades with targeted kinase inhibitors are a well-established strategy, drug-discovery efforts to identify targeted phosphatase inhibitors… (More)
- Frank Fan, Kang Yan, +12 authors David J Payne
- Antimicrobial agents and chemotherapy
- 2002
The MICs of triclosan for 31 clinical isolates of Staphylococcus aureus were 0.016 micro g/ml (24 strains), 1 to 2 micro g/ml (6 strains), and 0.25 micro g/ml (1 strain). All the strains for which… (More)
- Mark A. Seefeld, William Henry Miller, +17 authors William F. Huffman
- Journal of medicinal chemistry
- 2003
Bacterial enoyl-ACP reductase (FabI) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis and is an attractive target for the development of novel antibacterial agents.… (More)
- Anthony E. Choudhry, Tracy L. Mandichak, +8 authors Kapila Ratnam
- Antimicrobial agents and chemotherapy
- 2003
Pantothenate kinase (CoaA) catalyzes the first step of the coenzyme A biosynthetic pathway. Here we report the identification of the Staphylococcus aureus coaA gene and characterization of the… (More)
- William Henry Miller, Mark A. Seefeld, +16 authors William F. Huffman
- Journal of medicinal chemistry
- 2002
Bacterial enoyl-ACP reductase (FabI) catalyzes the final step in each cycle of bacterial fatty acid biosynthesis and is an attractive target for the development of new antibacterial agents. Our… (More)
- Melissa Dumble, Ming-Chih Crouthamel, +11 authors Rakesh Kumar
- PloS one
- 2014
Tumor cells upregulate many cell signaling pathways, with AKT being one of the key kinases to be activated in a variety of malignancies. GSK2110183 and GSK2141795 are orally bioavailable, potent… (More)
- David J Payne, William Henry Miller, +29 authors William F. Huffman
- Antimicrobial agents and chemotherapy
- 2002
Bacterial enoyl-acyl carrier protein (ACP) reductase (FabI) catalyzes the final step in each elongation cycle of bacterial fatty acid biosynthesis and is an attractive target for the development of… (More)
- Meagan B. Rouse, Mark A. Seefeld, +9 authors Dirk A. Heerding
- Bioorganic & medicinal chemistry letters
- 2009
AKT inhibitors containing an imidazopyridine aminofurazan scaffold have been optimized. We have previously disclosed identification of the AKT inhibitor GSK690693, which has been evaluated in… (More)
- Mark A. Seefeld, Meagan B. Rouse, +8 authors Dirk A. Heerding
- Bioorganic & medicinal chemistry letters
- 2009
A pyrrolopyridinyl thiophene carboxamide 7 was discovered as a tractable starting point for a lead optimization effort in an AKT kinase inhibition program. SAR studies aided by a co-crystal structure… (More)
- Mark A. Seefeld
- 2010