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Mixed-linkage ubiquitin chains send mixed messages.
Research on ubiquitin (Ub) signaling has focused primarily on homogeneously linked polyUb. Although polyUb containing different linkages within the same chain exist, their structures and signalingExpand
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Unique structural, dynamical, and functional properties of k11-linked polyubiquitin chains.
K11-linked polyubiquitin chains play important signaling and regulatory roles in both degradative and nonproteolytic pathways in eukaryotes. To understand the structural basis of how these chains areExpand
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Disassembly of Lys11 and Mixed Linkage Polyubiquitin Conjugates Provides Insights into Function of Proteasomal Deubiquitinases Rpn11 and Ubp6*
Background: Deconjugation of polyubiquitin is an essential step in preparing substrates for proteolysis by the 26S proteasome. Results: Proteasome-associated DUBs, Rpn11 and Ubp6, process long Lys11-Expand
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Extended ubiquitin species are protein-based DUB inhibitors
A frame-shift mutation in the transcript of the ubiquitin-B gene leads to a C-terminally extended ubiquitin, UBB+1. UBB+1 has been considered to inhibit proteasomes, and as such to be the underlyingExpand
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Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins.
Polyubiquitination, a critical protein post-translational modification, signals for a diverse set of cellular events via the different isopeptide linkages formed between the C terminus of oneExpand
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Chemical synthesis of phosphorylated ubiquitin and diubiquitin exposes positional sensitivities of e1-e2 enzymes and deubiquitinases.
Modification of ubiquitin by phosphorylation extends the signaling possibilities of this dynamic signal, as it could affect the activity of ligases and the processing of ubiquitin chains byExpand
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Base-CP proteasome can serve as a platform for stepwise lid formation
26S proteasome, a major regulatory protease in eukaryotes, consists of a 20S proteolytic core particle (CP) capped by a 19S regulatory particle (RP). The 19S RP is divisible into base and lidExpand
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Proteomic identification and analysis of K63-linked ubiquitin conjugates.
Post-translational modification of proteins by covalent attachment of ubiquitin or a polyubiquitin chain is involved in myriad of processes in eukaryotic cells. The particular outcome ofExpand
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Characterizing polyubiquitinated forms of the neurodegenerative ubiquitin mutant UBB+1
The ubiquitin mutant UBB+1 has been identified as a hallmark of neurodegenerative diseases. In this study, we characterize polyubiquitinated forms of UBB+1 in vitro and from patient samples. TheExpand
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Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway.
The discovery of ubistatins, small molecules that impair proteasomal degradation of proteins by directly binding to polyubiquitin, makes ubiquitin itself a potential therapeutic target. AlthoughExpand
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