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PURPOSE There are no robust data on prognostic factors for overall survival (OS) in patients with metastatic renal cell carcinoma (RCC) treated with vascular endothelial growth factor (VEGF) -targeted therapy. METHODS Baseline characteristics and outcomes on 645 patients with anti-VEGF therapy-naïve metastatic RCC were collected from three US and four(More)
BACKGROUND: We performed a retrospective population-based study to assess the impact of tyrosine kinase inhibitors (TKIs) on overall survival (OS) in patients treated for metastatic renal cell carcinoma (mRCC) in Alberta, Canada and to assess the impact of nephrectomy on OS in patients treated with TKIs. METHODS: We identified 134 patients who began taking(More)
Sixty teeth were stained in vitro to compare the decolorizing effect of three bleaching agents on the crowns and on the roots of teeth containing an intracoronal isolating base. With an intracoronal isolating base placed either at the cementoenamel junction (CEJ) or 2-mm below the CEJ, bleaching agents of Superoxol, sodium perborate, and a combination of(More)
The implementation of parallel molecular dynamics techniques is discussed in the context of the simulation of single-site anisotropic potentials. We describe the use of both replicated data and domain decomposition approaches to molecular dynamics and present results for systems of upto 65536 Gay-Berne molecules on a range of parallel computers (Transtech(More)
In this paper we present a molecular dynamics calculation of the Frank elastic constants of a nematic liquid crystal. We study two well-known variants of the Gay-Berne potential, and determine the elastic constants by measuring orientational fluctuations as a function of wavevector, using reasonably large system sizes in the range 1000–8000 molecules. For(More)
Leiomyosarcoma is a rare Epstein-Barr virus (EBV)-related complication of solid-organ transplantation. We report the case of a 19-year-old woman with cystic fibrosis who presented with protracted headaches 15 months after an EBV-mismatched bilateral sequential lung transplant. A parasagittal lesion was found on cranial magnetic resonance imaging; surgical(More)
/RESUME The 1992 Landers earthquake is perhaps the most famous earthquake for InSAR, having been the subject of many different scientific journal, magazine and newspaper articles. This plethora of papers means that the site is very well known and any attempt to process the data should be able to confidently predict the results. The ambiguity search method,(More)