Mark A. Warren

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BACKGROUND Atrial fibrillation (AF) commonly associates with atrial dilatation by poorly understood mechanisms. We hypothesized that elevation of intra-atrial pressure elicits high-frequency and spatio-temporally organized left atrial (LA) sources emanating from the superior pulmonary veins. METHODS AND RESULTS We used a stretch-related AF model in the(More)
The implementation of parallel molecular dynamics techniques is discussed in the context of the simulation of single-site anisotropic potentials. We describe the use of both replicated data and domain decomposition approaches to molecular dynamics and present results for systems of upto 65536 Gay-Berne molecules on a range of parallel computers (Transtech(More)
RATIONALE Deterioration of ventricular fibrillation (VF) into asystole or severe bradycardia (electrical failure) heralds a fatal outcome of cardiac arrest. The role of metabolism in the timing of electrical failure remains unknown. OBJECTIVE To determine metabolic factors of early electrical failure in an ex-vivo canine model of cardiac arrest (VF+global(More)
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