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We present the first of two articles on the small volume fraction limit of a nonlocal Cahn-Hilliard functional introduced to model microphase separation of diblock copoly-mers. Here we focus attention on the sharp-interface version of the functional and consider a limit in which the volume fraction tends to zero but the number of minority phases (called… (More)

We present the second of two articles on the small volume-fraction limit of a nonlocal Cahn–Hilliard functional introduced to model microphase separation of diblock copolymers. After having established the results for the sharp-interface version of the functional [SIAM we consider here the full diffuse-interface functional and address the limit in which ε… (More)

We consider analytical and numerical aspects of the phase diagram for microphase separation of diblock copolymers. Our approach is variational and is based upon a density functional theory which entails minimization of a nonlocal Cahn–Hilliard functional. Based upon two parameters which characterize the phase diagram, we give a preliminary analysis of the… (More)

A hallmark of a plethora of intracellular signaling pathways is the spatial separation of activation and deactivation processes that potentially results in precipitous gradients of activated proteins. The classical metabolic control analysis (MCA), which quantifies the influence of an individual process on a system variable as the control coefficient,… (More)

- Hong Manh, Duong, Mark A Peletier, Johannes Zimmer
- 2013

In this paper we discuss the connections between a Vlasov-Fokker-Planck equation and an underlying microscopic particle system, and we interpret those connections in the context of the GENERIC framework (¨ Ottinger 2005). This interpretation provides (a) a variational formulation for GENERIC systems, (b) insight into the origin of this variational… (More)

We revisit the classical problem of the buckling of a long thin axially compressed cylindrical shell. By examining the energy landscape of the perfect cylinder we deduce an estimate of the sensitivity of the shell to imperfections. Key to obtaining this is the existence of a mountain pass point for the system. We prove the existence on bounded domains of… (More)

- Christof Francke, Pieter W Postma, Hans V Westerhoff, Joke G Blom, Mark A Peletier
- Biophysical journal
- 2003

We calculated the implications of diffusion for the phosphoenolpyruvate:glucose phosphotransferase system (glucose-PTS) of Escherichia coli in silicon cells of various magnitudes. For a cell of bacterial size, diffusion limitation of glucose influx was negligible. Nevertheless, a significant concentration gradient for one of the enzyme species,… (More)

This is a study of the existence of bifurcation branches for the problem of finding even, periodic solutions in fourth-order, reversible Hamiltonian systems such that the Hamiltonian evaluates to zero along each solution on the branch. The class considered here is a generalization of both the Swift–Hohenberg and extended Fisher–Kolmogorov equations that… (More)

We study the limit of high activation energy of a special Fokker–Planck equation known as the Kramers–Smoluchowski equation (KS). This equation governs the time evolution of the probability density of a particle performing a Brownian motion under the influence of a chemical potential H/ε. We choose H having two wells corresponding to two chemical states A… (More)