Mark A Moore

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The use of glutaraldehyde-treated biological tissue in heart valve substitutes is an important option in the treatment of heart valve disease. These devices have limited durability, in part, because of tissue calcification and subsequent tearing of the valve leaflets. Components thought to induce calcification include lipids, cell remnants, and residual(More)
BACKGROUND AND AIMS OF THE STUDY Photooxidation of pericardium has been shown chemically to alter and stabilize tissue. The characterization of photooxidatively induced, chemical modifications of bovine pericardial and arterial tissue is reported here. METHODS Tissues were prepared by various methods of photooxidation and analyzed for thermal denaturation(More)
PURPOSE Aortic wall calcification is problematic in stentless porcine valves. We evaluated the possible anticalcification effect of photo-oxidation on the aortic wall portion of porcine stentless bioprostheses. A comparison with glutaraldehyde-fixed tissue was made. METHODS Six Photofix and six Freestyle valves were implanted in juvenile sheep in(More)
BACKGROUND Previous studies demonstrated that dye-mediated photooxidation can stabilize bovine pericardium. Here, photooxidized porcine valve cusp and root tissue were assessed in comparison to fresh and glutaraldehyde-treated samples. METHODS AND RESULTS In an in vitro tissue solubility test, both photooxidized and glutaraldehyde-treated tissues were(More)
Bovine pericardial tissue was stabilized through a dye-mediated photooxidation reaction. Shrink temperature analysis of the stabilized tissue indicated a material with similar properties to untreated pericardial tissue and unlike identical tissue treated with glutaraldehyde. Photooxidized tissue was resistant to extraction when compared with untreated(More)
A new approach for the replacement of heart valves consists of obtaining an acellular matrix from animal aortic valves that performs mechanically, is nonantigenic, and is free from calcification and fibroblast proliferation. Novel biochemical treatments must be developed for this purpose. In this work, we focus on the characterization of collagen in(More)
Using Raman microspectroscopy, we have studied mineral deposition on bovine pericardia, fixed according to three different protocols and either implanted subcutaneously or not implanted (controls). A lightly carbonated apatitic phosphate mineral, similar to that found in bone tissue, was deposited on the surface of a glutaraldehyde-fixed, implanted(More)
BACKGROUND AND AIMS OF THE STUDY Bovine and porcine pericardial tissues stabilized by dye-mediated photooxidation have found application as bioprosthetic heart valve material. METHODS To help predict clinical performance, a series of tests were performed to assess the biocompatibility and immunologic properties of these materials. RESULTS AND(More)
  • Mark A Moore
  • Journal of long-term effects of medical implants
  • 2001
The use of biological materials in prosthetic heart valves is widespread. Other articles in this issue address many key aspects of these materials. Fixation treatments, biological characteristics, mechanical performance and dysfunction, and the promise of tissue engineering are all discussed. The rest of this issue serves as an introduction to the many(More)