Marjorie A. Burkhart

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We have demonstrated previously that the C-terminal gamma interferon (IFN-gamma) mimetic peptide consisting of residues 95 to 133 [IFN-gamma(95-133)], which contains the crucial IFN-gamma nuclear localization sequence (NLS), has antiviral activity in tissue culture. Here we evaluate the efficacy of this peptide and its derivatives first in vitro and then in(More)
Prior research has inferred attentional changes related to depression from evidence concerning other cognitive processes. The present experiment investigated attentional changes related to depression in a more direct manner. Subjects were 32 young adults attending college. Depression was measured by self-report measures. In an auditory selective attention(More)
We have developed peptide mimetics of gamma interferon (IFN-gamma) that play a direct role in the activation and nuclear translocation of STAT1alpha transcription factor. These mimetics do not act through recognition by the extracellular domain of IFN-gamma receptor but rather bind to the cytoplasmic domain of the receptor chain 1, IFNGR-1, and thereby(More)
The Gamma Interferon (IFN) Mimetic Peptide IFN(95-133) Prevents Encephalomyocarditis Virus Infection both in Tissue Culture and in Mice Mustafa G. Mujtaba,* Chintak B. Patel, Ravi A. Patel, Lawrence O. Flowers, Marjorie A. Burkhart, Lilian W. Waiboci, James Martin, Mohammad I. Haider, Chulbul M. Ahmed, and Howard M. Johnson Department of Microbiology and(More)
Intracellularly expressed interferon gamma (IFNgamma) has been reported to possess biological activity similar to that of IFNgamma added to cells. This study addresses the mechanisms for such similar biological effects. Adenoviral vectors were used to express a non-secreted form of human IFNgamma or a non-secreted mutant form in which a previously(More)
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